US energy shares down on oil price fall
(Closed): US shares were mixed, as a rise in biotech stocks offset a fall in energy shares caused by a sharp drop in the oil price.
The Dow Jones fell 23.15 points to 18,529.42.
The announcement that US cancer drug firm Medivation would be purchased by pharmaceutical giant Pfizer sent its shares soaring 19.7%.
Pfizer shares were down 0.4%.
Crude prices fell 3.4% on signs of rising supplies. Brent crude fell to $49.16 a barrel, while US oil dropped to $47.43.
Aside from the oil price fall, investors are cautious ahead of the annual meeting of central bankers later this week in Jackson Hole, Wyoming.
"It's oil and then we've got Jackson Hole hanging over us, and there is always some surprise that comes out of Jackson Hole," said Jack Ablin, chief investment officer at BMO Private Bank, in Chicago.
Federal Reserve chairwoman Janet Yellen will deliver a speech on Friday, which will be scrutinised for clues as to the timing of the next US interest rate rise.
Computer chipmaker Intersil jumped 19.8% after a report that Japanese firm Renesas was in the final stages of negotiations to buy it for $2.99bn.