The driver of a transit van died when his vehicle caught fire after crashing on the M1 near Milton Keynes.
The van was involved in a collision with a lorry between junctions 14 and 13 just before midnight on Friday.
The van caught fire and the man, who has not been named, died at the scene, Bedfordshire Police said.
The motorway was closed for seven hours after the accident. The driver of the lorry was not injured, a police spokeswoman added.