The Liberal Democrat leader of Cardiff council says he wants to be a candidate at the Welsh assembly election next May.
Rodney Berman, 41, says he will put his name forward for nomination as the candidate in Cardiff Central.
Jenny Randerson has announced that she will stand down after holding the seat since the assembly was created in 1999.
Ms Randerson held a majority of 6,565 over Labour at the last election in 2007.
"I want to continue with the excellent work Jenny has done," said Mr Berman.
Glasgow-born Mr Berman was Ms Randerson's campaign manager when she first won the seat.
"Large numbers of friends and colleagues have encouraged me to seek the nomination," he said.
"And, after some considerable thought, I have decided to put my name forward."
Mr Berman, who stood for parliament in Cardiff South and Penarth in 2001 and in Rhondda in 1997, said he expected to see significant interest from fellow party members in the vacancy.
"The local party will have to decide how it wishes to proceed with the contest in the coming weeks," he said.
"There is no doubt that Jenny has been a terrific and tireless representative for the people of Cardiff Central.
"She will most certainly be a tough act to follow."