As seismic as it may be for Manchester City to win their first top-flight championship in 44 years, thereby denying their arch rivals Manchester United, both teams will be concentrating first on keeping 11 players on the field when they lock horns on Monday at Etihad Stadium.
Ignoring the Community Shield, previous encounters this season have involved a man being sent off, with Jonny Evans seeing red in City's 6-1 rout at Old Trafford and Vincent Kompany dismissed during United's 3-2 FA Cup victory across town.
Both punishments had an adverse effect on the respective games, although City did stage a fight-back in the second half of the third-round cup tie following their skipper's first-half departure.
So with City three points behind United and needing the win far more than their neighbours, how will managers Roberto Mancini and Sir Alex Ferguson prepare their teams ahead of the potentially historic derby?
Former United midfielder Nicky Butt and ex-City striker Uwe Rosler assess the key contests on the pitch and explain where they think the game will be won and lost.