Ramsey has chance to shine against Wilshere
So how do Wales cope against England without the injured Gareth Bale? The answer for former Wales midfielder Robbie Savage is a simple one.
"If I was Wales manager Gary Speed I would ring up Ryan Giggs and get him to play for one game only," he says. "It would give everybody a lift because the whole nation is feeling down at the minute."
It sounds like a sign of desperation but sums up the mood of losing arguably the Premier League's most exciting talent only days before the Euro 2012 qualifier in Cardiff.
The problem will certainly test Speed in his first qualifying game since taking charge last December.
Where once he might have been thinking of unleashing the pace of Bale and Craig Bellamy down either wing, he now has to come up with a different plan.
Savage says there is no point in holding back, though, given that Speed's side are bottom of Euro 2012 Group G having lost their first three games.
"They've got nothing to lose. They are not going to qualify and it's a game against your nearest rivals so you may as well attack England and go for it," he says.
"Everybody expects you to lose and no one gives you a chance other than the people inside the dressing room so you may as well put on a spectacle.
"Welsh people will not be satisfied with a defensive performance, they want to see Bellamy and they would have loved to have seen Bale, but they have other players like Aaron Ramsey's flair in midfield so I think they want to see a performance."
In Bale's absence much could fall on young Ramsey's shoulders after he was named as the new Wales captain by Speed on Thursday.
The 20-year-old has not played for his country since the 3-0 victory over Scotland in November 2009 and has had to recover from a bad leg-break suffered while playing for Arsenal against Stoke just over a year ago.
Savage believes the appointment is a good one as Ramsey will be a regular fixture for the Wales team in future years.
And he also thinks there is a player on Saturday who may help focus his mind.
During the past year, while Ramsey has spent periods of his recovery on loan at Nottingham Forest and Cardiff, he has had to watch the emergence of Arsenal team-mate Jack Wilshere.
A year younger than Ramsey, the England midfielder has enhanced his growing reputation in Champions League ties against Barcelona and has had England boss Fabio Capello raving about his potential.
"Before Ramsey was injured he was probably ahead of Wilshere in the Arsenal team," Savage adds. "But since his injury Wilshere has shown that he is a tremendous talent, probably one of the best talents England has seen for a long, long time.
"It will be a good battle between the two because Ramsey will feel Wilshere has taken over his slot at their club and he will be looking to prove a bit of a point."
For such a hotly contested game on Saturday, there may be a temptation for Capello to side with experience in England's midfield.
But former England captain and Match of the Day pundit Alan Shearer thinks that England need to go on the attack and that means playing 19-year-old Wilshere from the start.
"Wilshere will be able to handle the atmosphere, no problem," says Shearer. "He's played in the Nou Camp and The Emirates against Barcelona and arguably he was Arsenal's best player on both occasions.
"Frank Lampard is very good player and his scoring record at Chelsea and for England has shown that. It's hard to know who Capello will pick in central midfield but it might be a good combination with those pair."
Last month during England's 2-1 victory over Denmark, Capello paired Wilshere and Frank Lampard in the first half, with Barry alongside Scott Parker in the second and it offered a marked contrast.
While Capello was at pains to stress before the game that Wilshere was picked as a defensive midfielder with Lampard given licence to roam further forward, the Arsenal teenager actually played in a role similar to the one he plays at his club.
Touches from the first half show that Wilshere did a lot of his work in the opposition half and played quite narrowly, whereas Lampard, who was prepared to come deep and pick up the ball, provided more width.
During the second half of the friendly international in February, Barry and Parker offered a more solid approach with neither making too many inroads into the final third of the field.
But did that allow England's forwards, which included the winning goalscorer Ashley Young, the freedom to prosper?
Bale's injury might alter Capello's midfield thinking and he has also a dilemma further forward.
With Wayne Rooney recently restored to a more withdrawn role at Manchester United playing behind striker Javier Hernandez, Capello will choose a partner from Darren Bent, Jermaine Defoe, Andy Carroll and Pete Crouch.
"I wouldn't be surprised if Carroll started with Rooney up front as it has the potential to be a very good partnership," Shearer adds. "Both can work off each other as Andy will obviously win his fair share of balls in the air and Wayne will pick them up and work in and around him because he is world class.
"I have seen signs of Rooney returning to his former self and that has largely been shown by his return to goalscoring form. I'm not sure if he is at his very best yet but he looks to have a spring in his step again."
That should prove enough for England to win, Shearer says.
But assuming that Giggs stays as a spectator, Ramsey has a chance to show a huge audience that Wales' future hopes do not rest solely with Bale.
Robbie Savage will will be appearing Football Focus, live from Cardiff on BBC One at 1215 on Saturday. He will also present 606 on BBC Radio 5 live after the game.