Defence against infection

The body is constantly defending against attacks from pathogens. The first line of defence against infection stops the pathogens from entering your body. These first lines are general defences, and are not specific to fight against certain types of pathogen. We call this non-specific, and they can be physical or chemical barriers.

Physical barriers against infection


The skin covers almost all parts of your body to prevent infection from pathogens. If it is cut or grazed it immediately begins to heal itself, often by forming a scab, which prevents infection as the skin acts as a physical barrier. Parts of the body that do not have skin have developed other ways to prevent infection. For example, the eyes produce tears which contain enzymes. These enzymes are chemical barriers.

Diagram of a cross section of hair and below the surface of the skinCross-section of skin


The nose has internal hairs, which act as a physical barrier to infection. Cells in the nose produce mucus. This traps pathogens before they can enter the lungs. When the nose is blown, mucus is removed and any pathogens are trapped within it.

Mucus and ciliated cells

The trachea runs from the nose towards the lungs. The cells that line the trachea also have hairs called cilia, which are much smaller than those in the nose. These are called ciliated cells. The ciliated cells waft their hairs in a motion like a Mexican wave at a football match and move mucus and pathogens upwards towards the throat where it is swallowed into your stomach. Other cells called goblet cells create the mucus in order to trap pathogens. The production of mucus in your airways is a physical barrier.

A picture of ciliated cells. The cells have groups of hair sticking out of them. These are the cilia.
Ciliated cells in the airways waft away dust and pathogens trapped in mucus

Chemical barriers against infection

Stomach acid

The hydrochloric acid in our stomachs does not break down food. It is part of the body's non-specific first line of defence. It is hydrochloric acid and while it does us no harm, it is strong enough to kill any pathogens that have been caught in mucus in the airways or consumed in food or water. Stomach acid is a chemical barrier against infection.


To stop eye infections we have evolved chemicals within our tears called lysozymes. These are enzymes that destroy bacterial cells by breaking down their cell walls. Lysozymes are found in saliva, breast milk and mucus, as well as in tears. Lysozymes are chemicals so, like stomach acid, they are a form of chemical defence against infection.

A picture of an eye affected by conjuctivitis. The membrane around the eye is red sore and inflamed.

Conjunctivitis can occur if pathogens are not killed by lysozymes