Role of glucagon in control of blood sugar levels - Higher

Negative feedback

In blood glucose regulation, the hormone insulin plays a key role. When blood sugar rises in the blood, insulin sends a signal to the liver, muscles and other cells to store the excess glucose. Some is stored as body fat and other is stored as glycogen in the liver and muscles. If the blood glucose level is too low, the pancreas releases the hormone glucagon. This travels to the liver in the blood and causes the break-down of glycogen into glucose. The glucose enters the blood stream and glucose levels increase back to normal.

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A flowchart to demonstrate negative feedback

How glucose is regulated

Blood glucosePancreasLiverEffect on glucose
Too highInsulin secreted into the bloodLiver converts glucose into glycogenGoes down
Too lowGlucagon (not insulin) is secreted into the blood.Liver does not convert glucose into glycogen. Glycogen is converted to glucose.Goes up
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