Scientists working with the World Health Organisation say they have found the first evidence of resistance to the world's most effective anti-malaria drugs.
The scientists say that until now the drugs, which are from the artemesinin family, cleared all malaria parasites from the blood within two or three days.
But in recent trials, clearance sometimes took four or five days: an early sign of emerging resistance.
The BBC's Jill McGivering is in Pailin in western Cambodia, where the results of the first international trials are just coming through.

To play this content JavaScript must be turned on and the latest Flash player installed.
So how worried should we be?
The BBC's Claire Bolderson asked Dr Pascal Ringwald, the Medical Officer in charge of anti-malarial programmes at the WHO, what is meant by drug resistance.

To play this content JavaScript must be turned on and the latest Flash player installed.
First broadcast 29 May 2009
© 2012
The BBC is not responsible for the content of external sites. Read more.
This page is best viewed in an up-to-date web browser with style sheets (CSS) enabled. While you will be able to view the content of this page in your current browser, you will not be able to get the full visual experience. Please consider upgrading your browser software or enabling style sheets (CSS) if you are able to do so.