Watkins (left) won 17 Wales caps while Brew has been capped once
Newport Gwent Dragons have confirmed that former Wales internationals Matthew Watkins and Nathan Brew are among 16 players released.
Joe Bearman had already announced he would join the Ospreys
when his Rodney Parade contract expires in the summer.
But new coach
starts his first close season with a clear out.
Wales Sevens centre Rhodri Gomer Davies is to leave and hooker Duane Goodfield retires because of a shoulder injury.
Centre Watkins has played just five games this season while wing Brew has featured just three times, as the Dragons finished seventh in the Magners League.
Props Ali McKenzie and Pat Palmer, hookers Arthur Ellis and Craig Attwell, locks Rhydian Wilson and Adam Brown, number eight James Thomas, centre Tom Cooper, flanker James Davies, scrum-half Nicky Griffiths and Canadian full-back Matt Evans have also been released.
"It is a part of rugby that the end of each season sees a certain amount of player movement," said Dragons director of rugby, Robert Beale.
"These players have all put in a great deal of effort for the Dragons and we would like to thank them for the commitment they have shown to the region during their time here."