Usain Bolt returns to centre stage as he tries to win the 200m - and the Olympic sprint double - for the second time, after open water swimmer Keri-Anne Payne and boxer Nicola Adams try to add to Britain's medal tally.
Full schedule available on BBC Sport website
Bolt recently suggested he could run under 19 seconds for the 200m. If he manages that in Thursday's final, it will be one of the greatest must-see moments in athletics history.
Kenya's David Rudisha might not have the international profile of Bolt but he could produce something almost as special in the 800m final at 20:00, which also features Britain's Andrew Osagie. And all the teams will be hoping to avoid mishaps in the first round of the sprint relays.
Britain's Payne will start as the event favourite, having claimed two World Championship titles since her open-water silver in Beijing, but the 22-year-old has had a difficult year.
Read up on the protagonists:
She has struggled with back and shoulder injuries as well as a kidney infection, although Hyde Park's Serpentine course should play to her strengths.
London 2012 is the first Olympics to include women's boxing in the programme. After defeating Mary Kom in the semi-finals, GB's Adams has the chance to become the sport's first-ever Olympic champion when she faces three-time world champion Ren Cancan of China.
After winning GB's historic 20th gold medal of London 2012 with team victory on Tuesday, each of the British riders will be back to compete against one another in the individual dressage Grand Prix freestyle final. Having set an Olympic record in the team event last week, Dujardin will expect to be in the mix for another medal.
Great Britain's men will attempt to go
one step further than their female counterparts
by reaching the hockey final. Doing so would guarantee them at least a silver medal, but they will need to beat Netherlands to do it, who have won all of their matches so far at the Games. Australia meet Germany (15:30) in the other semi-final.
Great Britain's Luke Patience and Stuart Bithell are guaranteed at least silver in sailing's 470 class on Thursday but could go one better if the otherwise-dominant Australian crew of Mathew Belcher and Malcolm Page have an off-day. Realistically, nothing short of a win in the medal race can improve GB's standing. Even then, it is in the hands of the Australians. But an exciting climax and a medal are both promised.
Jade Jones, the 19-year-old from Flintshire, faces Serbia's Dragana Gladovic in her opening fight on Thursday. As the fourth seed, she has a draw that might help her reach the finals (19:55). Liverpudlian Martin Stamper begins against Mexico's Erick Osornio Nunez at 10:45.
Rachel Cawthorn set the 10th-fastest time in Tuesday's K1 500m sprint canoe semi-finals at Dorney Lake, but she came through second-fastest from her semi. If a fast field drags her pace up in Thursday's final, she could be a medal threat. Hungary's Danuta Kozak was fastest in the semis, two seconds up on Cawthorn, with South Africa's Bridgitte Hartley second.