The velodrome has been a happy hunting ground for Great Britain at recent Olympics, so the start of track cycling will raise hopes of further medal success for the home nation in London.
Here are Thursday's events to watch out for (all times BST):
Full schedule available on BBC Sport website
Pendleton and Hoy became household names after their performances in Beijing and will be among the favourites in their respective team sprints as the track cycling competition begins at London 2012.
Jess Varnish will partner Pendleton as the women's event makes its Olympic debut, with Germans Kristina Vogel and Miriam Welte and Australians Anna Meares and Kaarle McCulloch the serious challengers.
Hoy teams up with 19-year-old German-born Philip Hindes and Jason Kenny, who has been picked ahead of the Scot for the individual sprint. Australia, Germany and France will be among the leading threats.
Read up on the protagonists:
After a gold and a bronze on the first day of finals at Eton Dorney, the main British hopes on Thursday lie with the men's lightweight four of Richard Chambers, Peter Chambers, Rob Williams and Chris Bartley. Injuries affected the crew earlier this year but they won the last of this season's World Cup races, and their form suggests gold is a real possibility. Olympic champions Denmark are the major threat.
Fran Halsall is Britain's outstanding hope in the sprint final after coming through the semi-finals as the fifth-fastest qualifier. The rivalry between American greats Michael Phelps and Ryan Lochte will continue in the men's 200m individual medley final, with Briton James Goddard also involved. Earlier in the day, Rebecca Adlington starts the defence of her 800m freestyle title.
David Florence and Richard Hounslow have been in great form in the C2 this year, while British hopes have been further boosted by the qualification of Tim Baillie and Etienne Scott. The fastest six go through to the final at 13:48. The best bet for a medal might yet be Lizzie Neave, who was second fastest in qualification for the K1.
The battle for gold is expected to be a straight fight between the US and Russia. Gabby Douglas deprived 2011 world champion Jordyn Wieber of a place in this final, leaving the latter in tears, and could rival Russia's Aliya Mustafina for the title. Rebecca Tunney, the youngest Team GB member, and team-mate Hannah Whelan also made the final.
Britain's best chance of a shooting medal rests with Olympic debutant Peter Wilson, the world record holder and world number two. Former Olympic champion Richard Faulds is also in action for the hosts as they attempt to qualify for the afternoon final.
Basketball men v Spain 20:00, Handball men v Argentina 16:15, Hockey women v Belgium 19:00, Volleyball men v Italy 22:00, Water Polo women v Italy 18:20.
What are your must-see moments on Day Six?