Adam Le Fondre scored a second hat-trick in as many home games as Reading emphatically defeated managerless Blackpool.
The striker scored twice in a 10-minute spell in the first half, volleying in the opener before nodding in a second.
Pavel Pogrebnyak's angled effort made it 3-0, but Steve Davies's powerful drive gave Blackpool hope.
Le Fondre finished coolly for his third and Hal Robson-Kanu's 20-yard strike completed the win for Reading.
Blackpool bowled over
Managerless Blackpool have now lost 10 of their last 12 games
After a blistering start to the season that saw them top the Championship table in September, Blackpool have failed to win a game since November.
That poor run of form resulted in
of Paul Ince last week and his son Tom, who appears set for a move to the Premier League, was absent from the Blackpool squad at the Madejski stadium.
beat Bolton 7-1
in their last home game, with Le Fondre scoring a hat-trick and the former Rotherham striker was once again in lethal form.
He took just seven minutes to open the scoring when Garath McCleary's cross took a wicked deflection and Le Fondre reacted instinctively to volley in.
Le Fondre continued to cause Blackpool problems and, after shooting wide from another McCleary ball, he scored a second.
Alex Pearce headed Jobi McAnuff's ball across goal and Le Fondre headed in.
Blackpool had offered little, with Davies's ambitious 30-yard effort hitting the side-netting.
McAnuff was denied by goalkeeper Matt Gilks after racing through as Reading continued to press, and a third arrived soon after the break.
Kaspars Gorkss's header found Le Fondre, who in turn released Pogrebnyak and the Russian beat Gilks with a low effort.
Davies rifled in from 30 yards for Blackpool just after the hour but it was only a brief moment of relief as Le Fondre dinked over Gilks to complete his hat-trick.
Substitute Robson-Kanu then fired in from outside the area late on as sixth-place Reading sealed a victory that moves them four points clear of Ipswich.
Reading boss Nigel Adkins:
"Adam's three goals were just exceptional. It was a good team performance all round and there was a good level of consistency.
"A lot of that is down to being able to pick the same team for four matches in a row for the first time since I've been here. So it's no great surprise that we're now becoming more consistent.
"We've had a lot of players injured for a long period of time but we've got a good group of lads who are having a right go for each other. It bodes well for the remainder of the season."
Blackpool caretaker manager Barry Ferguson:
"I don't think you can play, captain and manage. I think it's better for me to take the team from the sidelines.
"I've still yet to find out what my situation is going to be. I don't know at the moment.
"It's a tough job management, in general, but apart from the result tonight, I really enjoyed it."
Reading 21 McCarthy 02 Gunter 37 Obita 16 Akpan 05 Pearce 17 Gorkss (Hector - 85' ) 12 McCleary 23 Williams 09 Le Fondre (Robson-Kanu - 74' ) 07 Pogrebnyak 11 McAnuff Booked (Blackman - 78' ) Substitutes 01 Federici 03 Kelly 10 Drenthe 19 Robson-Kanu 22 Blackman 25 Taylor 35 Hector Blackpool 01 Gilks 02 McMahon 03 Robinson 18 Osbourne (Martínez - 45' ) 06 Broadfoot 20 Cathcart 17 Basham 04 Perkins 09 Davies 08 Chopra (Tyson - 58' Booked ) 23 Eccleston (Halliday - 45' Booked ) Substitutes 07 Tyson 13 Warner 14 Halliday 22 Caton 25 Goodwillie 28 Dodd 31 Martínez
Ref: Kevin Friend