Ryan Williams' deflected effort saw Morecambe snatch a win at the Pirelli Stadium and end 10-man Burton's three-game winning run.
The visitors started brightly and almost went ahead when Kevin Ellison fired against the foot of the post.
Ellison then capitalised on a defensive error and his effort hit team-mate Williams to deflect into the net.
Chris Hussey volleyed wide in reply and Shane Cansdell-Sherriff was sent off for a second bookable offence.
VIEWS FROM THE DRESSING ROOM
Burton manager Gary Rowett told BBC Radio Derby:
"I felt a little bit disappointed really. It was a game that was pretty even.
"We've had an awful lot of the ball, an awful lot of opportunities to do something with it, but we've just not created clear chances and we didn't test them enough to win the game.
"I would probably say a draw would have been a fair result, but football's not fair at times.
"I was just disappointed by our lack of cutting edge at times in the game and I think that was the most disappointing factor for me."
Burton Albion 01 Pickford 02 Edwards 14 McCrory 23 Palmer Booked 06 Sharps Booked 25 Cansdell-Sherriff Dismissed after an earlier booking 17 Phillips (MacDonald - 58' ) 08 Weir 20 McGurk 29 Kee (Symes - 70' ) 03 Hussey (Knowles - 78' ) Substitutes 05 Diamond 07 Bell 11 MacDonald 16 Lyness 18 Knowles 22 Dyer 28 Symes Morecambe 01 Roche 08 Wright Booked 03 Threlfall 10 Williams 22 Parrish 05 Hughes Booked 17 Fleming Booked 16 Drummond (Kenyon - 76' Booked ) 09 Sampson (Marshall - 69' ) 27 Amond (Redshaw - 86' ) 11 Ellison Booked Substitutes 04 Kenyon 06 Diagne 07 Redshaw 14 Marshall 19 McGee 20 Mwasile 25 Arestidou
Ref: Tim Robinson