Leeds boss Brian McDermott endured an unhappy return to Reading, as Adam Le Fondre scored a 96th-minute winner for the Royals in the Championship.
The striker McDermott brought to the Madejski Stadium from Rotherham in 2011 converted from Royston Drenthe's free-kick to send his side seventh.
The chance came after Stephen Warnock received his second yellow card of the match for a trip on Le Fondre.
Luke Varney wasted the best chance for the visitors, who now sit 11th.
The result - a third successive clean sheet for Nigel Adkins' men - means Leeds have still never won at the Madejski Stadium.
The hosts had seen midfielder Jem Karacan carried off on a stretcher after just nine minutes, appearing to twist his right knee when challenging Ross McCormack.
Danny Williams and Hal Robson-Kanu tested Paddy Kenny, but the Leeds goalkeeper pushed both strikes away.
Leeds midfielder Rodolph Austin had two opportunities, striking a free-kick over the bar and sending a 25-yard attempt narrowly wide - the only noteworthy efforts for the visitors, Varney's weak effort aside.
Reading centre-back Sean Morrison twice headed high and wide from free-kicks and Nick Blackman saw his goalbound drive deflected wide by Warnock.
But the left-back's night turned sour when he was dismissed for his second bookable offence, and saw Le Fondre capitalise to give the hosts the three points.
Sorry, we were unable to load match stats, please try again.