Josh Brizell's first goal of the season helped Hyde beat Cambridge to move five points clear of the relegation zone.
Matthew Blinkhorn swept the hosts ahead after an incisive run from Louis Almond, before Liam Hughes headed home the equaliser from close range.
Tom Elliott missed a great chance to put the visitors ahead but failed to hit the target from six yards.
Brizell's winner was a thunderous shot from the edge of the box as Hyde won for the fourth game in a row.
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