Plymouth goalkeeper Jake Cole condemned his side to defeat with a second-half blunder as Northampton stayed in the thick of the promotion picture.
Cole fumbled a corner under pressure from Cobblers skipper Kelvin Langmead, allowing Clive Platt to force home.
It spoiled an otherwise competent display which saw him save from Roy O'Donovan, Harding and Bayo Akinfenwa.
Former Northampton defender Anthony Charles had a late chance to snatch a point but headed wide from a corner.
VIEWS FROM THE DRESSING ROOM
Northampton Town manager Aidy Boothroyd tells BBC Radio Northampton:
"We were made to scrap for it. We didn't play very well today, but it's about winning.
"Only Lee Collins and Roy O'Donovan played up to their normal levels and the rest were a tad below par, but that's how it is sometimes.
"There was a bit of fortune with the goal, but we didn't get very much fortune at AFC Wimbledon, so it's evened itself out.
"Everyone has their favourites on team selection, but it's me who picks the team. At times today, we looked good, but we know we can play better."
Plymouth Argyle manager John Sheridan told BBC Radio Devon:
"It was a ridiculous goal. I'll go in and see the referee and I'll ask him the question 'Who scored the goal?'.
"It was a clear foul on the keeper and it's only the ref that doesn't see it.
"But he's probably never played football so he won't have seen what the foul was. Get ex-players in officiating who know the game.
"We're in a scrap but we have to be realistic. We have to look at how we're going to create more chances and score goals to win games."
Northampton 21 Nicholls 02 Johnson (Akinfenwa - 60' ) 05 Langmead 06 Collins 12 Tozer 30 Carlisle 08 Harding 11 Hackett 22 Hornby 09 Platt (Robinson - 87' ) 28 O'Donovan Substitutes 13 Snedker 18 Artell 04 Guttridge 07 Demontagnac 23 Oyeleke 10 Akinfenwa 17 Robinson Plymouth Argyle 01 Cole 04 Blanchard 05 Branston 14 Bhasera Booked 26 Charles 06 Hourihane 10 Cox 15 Wotton Booked (Gurrieri - 77' ) 19 Banton 07 Cowan-Hall (Ugwu - 74' ) 24 Reid (Murray - 81' ) Substitutes 13 Chenoweth 23 Richards 08 Young 27 Gurrieri 18 Ugwu 28 Murray