Fleetwood extended their unbeaten run to four matches and moved to within two points of the League Two promotion places with a win at Oxford.
Ryan Crowther finished well for the Cod Army after good work from Conor McLaughlin and David Ball.
Junior Brown doubled the lead soon after the restart as his diving header beat Luke McCormick from close range.
Oxford's Alfie Potter had a header cleared off the line before Liam Davis's 20-yard goal for the home side.
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