An early first-half goal from Wycombe striker Matt McClure ended Plymouth Argyle's four-match unbeaten run.
Matthew Spring dispossessed Luke Young to play in McClure, who shot across keeper Rene Gilmartin to find the net.
Argyle had hit the woodwork shortly before, with Nick Chadwick's shot on the turn cannoning off a post.
Paris Cowan-Hall hit the bar after the break while Chadwick and Darren Purse headed narrowly wide as the home side could not find an equaliser.
VIEW FROM THE DRESSING ROOM
Plymouth Argyle manager Carl Fletcher told BBC Radio Devon:
"We dominated for ninety percent of the game.
"We just didn't put the ball in the back of the net, and that was the only difference. There was a lack of quality in the final five minutes.
"There's definitely people we want to get in, but we can't do it until we get the finances right."
Plymouth Argyle 20 Gilmartin 04 Blanchard 05 Purse 14 Bhasera (Molesley - 70' ) 17 Nelson 03 Williams 06 Hourihane 08 Young 07 Cowan-Hall 09 Chadwick (Griffiths - 70' ) 29 Harvey (Feeney - 56' Booked ) Substitutes 01 Cole 02 Berry 19 Lennox 27 Gurrieri 30 Molesley 10 Griffiths 11 Feeney Wycombe Wanderers 36 Archer 19 McCoy 27 Stewart 34 Hause 07 Ainsworth Booked (Morias - 85' ) 08 Lewis 09 Spring 11 Wood 12 Andrade Booked 22 Kuffour 29 McClure (Adebayo Azeez - 70' ) Substitutes 21 Harrison 25 Angol 35 Ehui 15 Oli 32 Morias 38 Adebayo Azeez