Blackpool's first game since the departure of Ian Holloway as manager ended in a heavy defeat at Derby.
Theo Robinson fired the Rams in front when he converted a Paul Coutts cross, and a long-range John Brayford strike added to Derby's lead.
Tom Ince scored a penalty after a Richard Keogh handball to pull one back for the visitors.
But Robinson surged into the box and slotted home before Conor Sammon tapped in to complete the scoring.
Holloway was confirmed as Crystal Palace manager earlier in the day and Steve Thompson took caretaker charge of the Tangerines.
But Thompson, who would like the job on a permanent basis, looked on as the Rams quickly took a grip on the game through Robinson's strike.
The Rams extended their lead when Coutts found Brayford, who powered in a 25-yard strike past keeper Matt Gilks.
Ince scored for the visitors from the penalty spot after a Matt Phillips shot was adjudged to have struck the hand of Keogh.
But five minutes later Robinson's seventh of the season gave Derby a two-goal cushion again.
The delivery of Coutts was a major weapon for the Rams and he crossed for Sammon to seal the victory with a Derby fourth.
Derby manager Nigel Clough:
"[Theo Robinson] was on a hat-trick so he wasn't exactly chuffed about it [when I substituted him].
"But he had been carrying a bit of a strain in training and with a game here against Barnsley on Tuesday it made sense to bring him off.
"If he's disappointed about it, he can score a hat-trick against them.
"It was the complete performance, exhilarating. We did everything right to take advantage of a difficult situation for Blackpool."
Live Text Commentary
Full Time The referee blows his whistle to end the game.90:00 +1:02
Direct free kick taken by James O'Connor.90:00 +1:02 Booking
Booking Chris Basham receives a caution for unsporting behaviour.90:00 +0:57
Free kick awarded for a foul by Chris Basham on Michael Jacobs.90:00 +0:32
Matt Gilks fouled by Michael Jacobs, the ref awards a free kick. Matt Gilks takes the free kick.86:38
Paul Coutts takes the direct free kick.86:38 Booking
Booking Ian Evatt booked for unsporting behaviour.86:24
Ian Evatt concedes a free kick for a foul on Kieron Freeman.84:31 Substitution
Substitution Michael Jacobs is brought on as a substitute for Will Hughes.82:57
Thomas Ince has a headed effort at goal from deep inside the area missing to the right of the target.82:25
Free kick awarded for an unfair challenge on Kirk Broadfoot by Will Hughes. Kirk Broadfoot takes the free kick.80:45 Substitution
Substitution Kieron Freeman is brought on as a substitute for Jeff Hendrick.80:45
Shot from outside the box by Craig Bryson hits the post.80:29
Paul Coutts restarts play with the free kick.80:29 Booking
Booking Thomas Ince booked.79:56
Thomas Ince concedes a free kick for a foul on Craig Bryson.79:00
Foul by Thomas Ince on Jeff Hendrick, free kick awarded. Direct free kick taken by Richard Keogh.77:12
Ludovic Sylvestre takes a shot. Save by Adam Legzdins.76:31
Gareth Roberts gives away a free kick for an unfair challenge on Chris Basham. The free kick is delivered left-footed by Thomas Ince from right wing, Conor Sammon makes a clearance.76:04
Free kick awarded for an unfair challenge on Kirk Broadfoot by Will Hughes. Matt Gilks takes the indirect free kick.
Substitution Chris Basham on for Elliot Grandin.71:33
Matt Phillips takes a shot. Blocked by John Brayford.70:04
Nathan Tyson is flagged offside by the assistant referee. Alex Baptiste takes the indirect free kick.68:12
Kirk Broadfoot has an effort at goal from deep inside the area missing to the right of the target.66:31 Substitution
Substitution Theo Robinson goes off and Nathan Tyson comes on.64:55 Substitution
Substitution Nouha Dicko comes on in place of Angel Martinez.64:55
Paul Coutts provided the assist for the goal.64:55 Goal scored
Goal! - Conor Sammon - Derby 4 - 1 Blackpool Conor Sammon gets on the score sheet with a goal from close range low into the middle of the goal. Derby 4-1 Blackpool.64:49
Centre by Paul Coutts,61:38
Effort on goal by Richard Keogh from deep inside the area goes harmlessly over the bar.59:11
Inswinging corner taken right-footed by Elliot Grandin from the left by-line.56:24
The assistant referee flags for offside against Theo Robinson. Free kick taken by Matt Gilks.55:43
Thomas Ince is caught offside. Indirect free kick taken by Adam Legzdins.54:35
Elliot Grandin takes a shot. Save made by Adam Legzdins.53:15 Goal scored
Goal! - Theo Robinson - Derby 3 - 1 Blackpool A goal is scored by Theo Robinson from close in to the bottom left corner of the goal. Derby 3-1 Blackpool.52:41
Outswinging corner taken by Paul Coutts from the right by-line, Matt Phillips makes a clearance.52:03
Short corner worked by Paul Coutts.51:49
Centre by Paul Coutts, clearance made by Alex Baptiste.50:23
Gary Taylor-Fletcher concedes a free kick for a foul on Gareth Roberts. Free kick taken by Paul Coutts.49:48
Gary Taylor-Fletcher takes a shot. James O'Connor gets a block in.48:57 Goal scored
Goal! - Thomas Ince - Derby 2 - 1 Blackpool Placed penalty scored by Thomas Ince. Derby 2-1 Blackpool.48:00
Matt Phillips takes a shot. Richard Keogh gets a block in. Richard Keogh handles the ball and concedes a .45:01
The referee blows his whistle to start the second half.45:00 +1:21 Half time
Half Time The referee calls an end to the first half.45:00 +0:12
Will Hughes takes a shot. Outswinging corner taken right-footed by Paul Coutts from the right by-line, clearance by Ian Evatt.44:34
Paul Coutts takes a short corner.44:18
Will Hughes takes a shot. Alex Baptiste gets a block in.41:57
Outswinging corner taken from the right by-line by Paul Coutts, clearance by Alex Baptiste.40:19
A cross is delivered by John Brayford.39:26
Jeff Hendrick challenges Angel Martinez unfairly and gives away a free kick. Angel Martinez takes the free kick.38:50
Free kick awarded for a foul by Gary Taylor-Fletcher on Jeff Hendrick. John Brayford takes the direct free kick.38:06
Shot by Matt Phillips from outside the box goes over the target.36:03
The assistant referee flags for offside against John Brayford. Matt Gilks takes the indirect free kick.35:09
James O'Connor fouled by Matt Phillips, the ref awards a free kick. Adam Legzdins takes the direct free kick.33:49
Corner taken right-footed by Paul Coutts, Ian Evatt makes a clearance.32:49
The referee blows for offside. Indirect free kick taken by Alex Baptiste.31:38
Paul Coutts takes a short corner.30:31
Assist on the goal came from Jeff Hendrick.30:31 Goal scored
Goal! - John Brayford - Derby 2 - 0 Blackpool Goal scored by John Brayford from just inside the penalty area to the top left corner of the goal. Derby 2-0 Blackpool.30:04
Corner taken short by Paul Coutts.28:33
Will Hughes sends in a cross.26:42
The referee blows for offside against Conor Sammon. Matt Gilks restarts play with the free kick.26:19
Paul Coutts produces a cross.24:05
Inswinging corner taken from the right by-line by Thomas Ince. Effort from just inside the area by Ludovic Sylvestre hits the post. Corner taken by Elliot Grandin from the left by-line.22:49
Gary Taylor-Fletcher takes a shot. Richard Keogh gets a block in.22:27
Craig Bryson sends in a cross, save by Matt Gilks.20:21
The referee blows for offside against Jeff Hendrick. Matt Gilks takes the indirect free kick.19:18
Gary Taylor-Fletcher takes a shot. Richard Keogh gets a block in. Outswinging corner taken right-footed by Matt Phillips, save by Adam Legzdins.18:15
Alex Baptiste fouled by Conor Sammon, the ref awards a free kick. Matt Gilks takes the free kick.15:05
Matt Phillips produces a cross.13:12
Corner taken by Paul Coutts from the right by-line, Kirk Broadfoot makes a clearance.12:31
The assistant referee signals for offside against John Brayford. Matt Gilks restarts play with the free kick.11:23
The assist for the goal came from Paul Coutts.11:23 Goal scored
Goal! - Theo Robinson - Derby 1 - 0 Blackpool Theo Robinson finds the net with a goal from inside the penalty area to the bottom right corner of the goal. Derby 1-0 Blackpool.10:01
The assistant referee signals for offside against Theo Robinson. Free kick taken by Matt Gilks.8:36
The ball is crossed by Paul Coutts, clearance made by Ian Evatt. Outswinging corner taken by Paul Coutts from the right by-line played to the near post, clearance by Kirk Broadfoot. Short corner taken by Paul Coutts.7:04
Handball by Gary Taylor-Fletcher. Craig Bryson takes the direct free kick.6:09
Will Hughes takes a short corner.5:14
Theo Robinson takes a shot. Save made by Matt Gilks. Foul by Stephen Crainey on John Brayford, free kick awarded. Free kick taken by Paul Coutts.2:24
Craig Bryson produces a cross.0:39
Gareth Roberts fouled by Matt Phillips, the ref awards a free kick. Paul Coutts restarts play with the free kick.0:00
The match begins.
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