Ross Barkley added to managerless Ipswich's woes as Sheffield Wednesday secured their first Championship away win since January 2010.
Barkley, on loan from Everton, rifled home the first goal following Michail Antonio's cross before adding a second from 20 yards after the interval.
Antonio added a third from close range in the closing stages after being teed-up by Chris O'Grady.
Ipswich, searching for a new boss after Paul Jewell resigned , remain bottom.
A fourth straight defeat will intensify the search to find a replacement for Jewell.
Ipswich, without a win in 11 matches, fell behind in the second minute when England Under-21 international Barkley, 18, fired low under keeper Stephen Henderson after Lewis Buxton's shot was blocked by Luke Hyam.
The hosts had chances to haul themselves back into the game.
Aaron Cresswell's 20-yard free-kick flew over the bar, fellow midfielder Richie Wellens fired a 25-yard shot just over and Danny Higginbotham headed Lee Martin's free-kick narrowly wide in the 40th minute.
But Ipswich found themselves 2-0 behind in the 58th minute when Barkley stepped inside on the edge of the area and arrowed a low shot into the net.
The home team's misery was complete when O'Grady played the ball across the six-yard area for Antonio to convert the simplest of finishes.
Ipswich caretaker manager Chris Hutchings:
"I'm angry and disappointed. The players let themselves down and need to look in the mirror. They should be professional and have a desire and drive to perform.
"That's their job and they're well paid to do it. But they haven't done so for a little while and that's why we're adrift at the bottom of the table.
"One or two of the older players didn't perform anywhere near as well as they can do."
Sheffield Wednesday manager Dave Jones:
"Our performances have been good for five or six games. We've been dominating but the only thing we haven't been doing is putting the ball in the back of the net.
"We feel hard done by not to have more points, but today we had to stick to what we believe in. We had to believe things would turn and Ipswich felt the full force.
"The second goal killed them off and then we had a game of keep-ball.
"It's a ruthless game and if you get it right, it can be disheartening for the other team."
Live Text Commentary
Full Time The match has reached full-time.90:00 +2:13
Indirect free kick taken by Ross Barkley.90:00 +2:13 Booking
Booking Luke Chambers is cautioned.90:00 +2:07
Free kick awarded for a foul by Luke Chambers on Jay Bothroyd.90:00 +1:24
Bilel Mohsni fouled by Michail Antonio, the ref awards a free kick. Free kick crossed left-footed by Jay Emmanuel-Thomas, clearance by Anthony Gardner.90:00 +0:15
Bilel Mohsni takes a shot from deep inside the box clearing the bar.89:58
Aaron Cresswell delivers the ball, clearance made by Anthony Gardner.89:12
The ball is delivered by Michael Chopra, Jose Semedo gets a block in. Corner taken left-footed by Jay Emmanuel-Thomas from the right by-line, Chris Kirkland makes a save.87:28
Michael Chopra takes a shot from deep inside the box clearing the bar.82:45 Substitution
Substitution Bilel Mohsni is brought on as a substitute for DJ Campbell.80:23
Assist on the goal came from Chris O'Grady.80:23 Substitution
Substitution Gary Madine is brought on as a substitute for Chris O'Grady.80:23 Goal scored
Goal! - Michail Antonio - Ipswich 0 - 3 Sheff Wed Michail Antonio finds the back of the net with a goal from close range to the bottom right corner of the goal. Ipswich 0-3 Sheff Wed.79:42
Lee Martin sends in a cross, save by Chris Kirkland.76:53
Chris Kirkland restarts play with the free kick.76:53 Substitution
Substitution Josh Carson goes off and Jay Emmanuel-Thomas comes on.76:53
Daniel Jones fouled by Josh Carson, the ref awards a free kick.75:17
The ball is swung over by Lee Martin, save made by Chris Kirkland.74:14
Free kick awarded for an unfair challenge on Lee Martin by Ross Barkley. Free kick taken by Luke Hyam.71:45
Free kick taken by Chris Kirkland.
Substitution Paul Corry goes off and Jermaine Johnson comes on.71:45
DJ Campbell concedes a free kick for a foul on Miguel Llera.69:19
The ball is delivered by DJ Campbell, Anthony Gardner manages to make a clearance. Inswinging corner taken from the left by-line by Lee Martin, Daniel Jones manages to make a clearance.67:29
Free kick taken by Anthony Gardner.67:29 Booking
Booking Booking for Lee Martin for unsporting behaviour.67:24
Daniel Jones fouled by Lee Martin, the ref awards a free kick.66:08
Corner taken by Lee Martin, clearance made by Miguel Llera.65:50
Centre by Carlos Edwards, Anthony Gardner makes a clearance.64:40
The ball is sent over by Lee Martin, Jay Bothroyd manages to make a clearance.64:04
Aaron Cresswell restarts play with the free kick.64:04 Booking
Booking Jay Bothroyd shown a yellow card.64:03
Free kick awarded for a foul by Jay Bothroyd on Michael Chopra.62:46
Ross Barkley is flagged offside by the assistant referee. Danny Higginbotham takes the indirect free kick.61:07
Shot by Michail Antonio. Stephen Henderson makes a save.59:57
Stephen Henderson takes the indirect free kick.59:57 Substitution
Substitution Daryl Murphy goes off and Michael Chopra comes on.59:57
Free kick awarded for a foul by Chris O'Grady on Luke Chambers.58:00
Assist by Michail Antonio.58:00 Goal scored
Goal! - Ross Barkley - Ipswich 0 - 2 Sheff Wed Goal scored by Ross Barkley from just outside the penalty area to the bottom left corner of the goal. Ipswich 0-2 Sheff Wed.57:19
Daryl Murphy sends in a cross.55:04
Centre by Carlos Edwards, Michail Antonio manages to make a clearance.52:45
DJ Campbell takes a shot. Save by Chris Kirkland.51:30
Luke Chambers fouled by Chris O'Grady, the ref awards a free kick. Stephen Henderson takes the indirect free kick.50:26
Ross Barkley produces a left-footed shot from outside the penalty box and misses left.49:42
Lee Martin concedes a free kick for a foul on Michail Antonio. Chris Kirkland takes the indirect free kick.49:07
Daniel Jones challenges Josh Carson unfairly and gives away a free kick. Lee Martin crosses the ball in from the free kick, clearance made by Anthony Gardner.47:35
Carlos Edwards sends in a cross, Paul Corry gets a block in.45:57
The ball is delivered by Carlos Edwards, Miguel Llera manages to make a clearance.45:01
The referee blows his whistle to start the second half.45:00 +1:12 Half time
Half Time The first half comes to an end.45:00 +0:30
DJ Campbell is flagged offside by the assistant referee. Chris Kirkland takes the free kick.44:46
Josh Carson has an effort at goal. Save made by Chris Kirkland.43:29
Aaron Cresswell crosses the ball, Header from close range by Danny Higginbotham clears the bar.43:13
Josh Carson decides to take a short corner.41:55
Chris O'Grady challenges Luke Chambers unfairly and gives away a free kick. Luke Chambers takes the indirect free kick.41:27
Effort from outside the penalty area by Michail Antonio goes wide left of the target.39:16
The ball is delivered by Lee Martin, Daniel Jones is adjudged to have handled the ball. Centre by Lee Martin, Headed effort from deep inside the area by Danny Higginbotham misses to the left of the goal.36:07
Luke Hyam challenges Paul Corry unfairly and gives away a free kick. Miguel Llera takes the free kick.35:56
The ball is crossed by Lee Martin, Miguel Llera manages to make a clearance.34:14
Foul by Anthony Gardner on DJ Campbell, free kick awarded. Aaron Cresswell takes the indirect free kick. Shot from just outside the area by Richie Wellens goes over the bar.34:02
Centre by Josh Carson, clearance made by Anthony Gardner.31:27
The ball is sent over by Josh Carson. The offside flag is raised against DJ Campbell. Chris Kirkland takes the free kick.30:42
Free kick awarded for a foul by Lewis Buxton on Daryl Murphy. Aaron Cresswell takes the free kick.29:22
Chris O'Grady has a headed effort from close in and clears the bar.29:01
The ball is swung over by Paul Corry, Luke Chambers makes a clearance.28:29
Free kick awarded for an unfair challenge on Michail Antonio by Carlos Edwards. Free kick taken by Anthony Gardner.26:25
Foul by Daniel Jones on Josh Carson, free kick awarded. Shot comes in from Aaron Cresswell from the free kick.23:53
Aaron Cresswell produces a strike on goal direct from the free kick.23:53 Booking
Booking Anthony Gardner receives a caution.23:50
Free kick awarded for an unfair challenge on Lee Martin by Anthony Gardner.22:42
Lee Martin takes a shot. Jose Semedo gets a block in.20:53
Foul by Michail Antonio on Carlos Edwards, free kick awarded. Luke Chambers takes the indirect free kick.20:02
Chris O'Grady is flagged offside by the assistant referee. Stephen Henderson takes the free kick.19:34
The ball is crossed by Josh Carson, save by Chris Kirkland.18:31
Lewis Buxton challenges Daryl Murphy unfairly and gives away a free kick. Richie Wellens crosses the ball from the free kick right-footed from left wing, Anthony Gardner makes a clearance.17:53
A cross is delivered by Carlos Edwards, blocked by Michail Antonio.15:34
The ball is delivered by Jay Bothroyd, Michail Antonio takes a shot. Danny Higginbotham gets a block in. Corner taken left-footed by Jay Bothroyd, Miguel Llera challenges Stephen Henderson unfairly and gives away a free kick. Indirect free kick taken by Stephen Henderson.14:51
Michail Antonio produces a cross, blocked by Carlos Edwards. Corner taken left-footed by Jay Bothroyd from the right by-line, clearance by Luke Hyam.13:59
Michail Antonio has an effort at goal from the edge of the box that misses to the right of the target.12:26
Foul by Luke Hyam on Jay Bothroyd, free kick awarded. Jay Bothroyd takes the free kick.11:48
The ball is crossed by Jose Semedo.10:44
Chris O'Grady challenges Aaron Cresswell unfairly and gives away a free kick. Richie Wellens takes the indirect free kick.9:48
Free kick awarded for a foul by Jay Bothroyd on Daryl Murphy. Stephen Henderson takes the free kick.9:06
A cross is delivered by Lee Martin, Luke Hyam produces a right-footed shot from the edge of the box and misses to the left of the target.8:25
Corner taken left-footed by Josh Carson, Luke Chambers takes a shot. Save by Chris Kirkland.8:16
A cross is delivered by Daryl Murphy, Miguel Llera manages to make a clearance.6:54
Unfair challenge on Lee Martin by Jose Semedo results in a free kick. Free kick crossed left-footed by Aaron Cresswell from right wing.5:28
Daniel Jones crosses the ball, clearance made by Luke Hyam.3:00
Michail Antonio takes a shot. Save by Stephen Henderson.2:17
Corner taken by Jay Bothroyd, The referee gives a free kick against Michail Antonio for handball. Indirect free kick taken by Stephen Henderson.1:23 Goal scored
Goal! - Ross Barkley - Ipswich 0 - 1 Sheff Wed Ross Barkley scores a goal from deep inside the penalty box to the bottom right corner of the goal. Ipswich 0-1 Sheff Wed.0:10
Ross Barkley produces a cross, Luke Chambers manages to make a clearance.0:00
The referee gets the match started.
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