Simon Bassey slipped to his first defeat as caretaker manager of AFC Wimbledon at the hands of Accrington.
Padraig Amond finished with a neat chip to put the visitors ahead after Will Hatfield's shot was parried by Dons keeper Seb Brown.
Peter Murphy scored his third goal in four games with a stunning volley to double Accrington's lead.
Sammy Moore tapped in a late consolation for Wimbledon but they were unable to force an equaliser.
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