Jean-Louis Akpa Akpro scored twice on his league debut for Tranmere, who eased to victory over Leyton Orient.
Rovers' first goal came from an unlikely source, full-back Zoumana Bakayogo latching onto a pass from Wolves loanee Jake Cassidy to score.
And ex-Rochdale man Akpa Akpro netted a brace to put the result beyond doubt.
He fired home from 20 yards and headed in a James Wallace cross, before Orient's Michael Symes scored a late penalty after Bakayogo's handball.
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Leyton Orient manager Russell Slade told BBC London 94.9:
"We couldn't back up the really good performance on Tuesday.
"There were too many average or below-average performances from my players today.
"That second goal hurt because I felt we were on top and that second goal went against the run of play.
"The attitude was there but we need to play with more urgency."
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Tranmere Rovers 01 fon Williams Booked 02 Holmes 04 Taylor 14 Bakayogo 21 Gibson 06 Palmer 07 Thompson 08 Wallace 10 Robinson Booked (Bell-Baggie - 76' ) 09 Cassidy 26 Akpa Akpro (Stockton - 82' ) Substitutes 33 Mooney 19 Kay 12 Harrison 15 Kirby 17 Power 16 Stockton 22 Bell-Baggie Leyton Orient 01 Jones 03 Sawyer 05 Cuthbert (Chorley - 48' ) 06 Baudry Booked 15 Clarke 23 James 07 Cox Booked 08 Griffith 11 Smith 09 Lisbie (Symes - 69' Booked ) 39 Mooney (Brunt - 70' ) Substitutes 16 Allsopp 04 Chorley 02 McSweeney 14 Laird 17 Odubajo 10 Symes 26 Brunt
Ref: Geoff Eltrigham