Wycombe picked up a comfortable win and ensured that it would not be a happy return to the Football League for York.
Matt Bloomfield put the visitors ahead with a deflected strike from the edge of the area, before Sam Wood's superb 35-yard volley doubled the advantage.
And Stuart Beavon gave the Chairboys a three-goal cushion when he stroked home Stuart Lewis's cutback.
Jason Walker turned in Jonathan Smith's header for the hosts, but it was too little, too late.
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York City manager Gary Mills told BBC Radio York:
"I don't think we were on our game today. I don't think we played how we play.
"I don't think we were brave enough to play enough out back, I thought we put too many balls down their throats early on in the game, and for me that carried on until half-time.
"They scored a cracking goal for the second, but it's how they get those opportunities in the first place."
Wycombe midfielder Sam Wood told BBC Three Counties Radio:
"They say 'if you don't shoot, you don't score', so I thought I'd let one go and luckily it went in.
"As soon as it fell in front of me, I thought 'I'm just going to bang it'.
"I hit it and it felt nice and I saw it loop over the keeper. I didn't know what to do, whether to celebrate, laugh or whatever.
"Momentum was with them after getting promoted and winning the (FA) Trophy as well. We knew it was going to be tough, but we were clinical, we took our chances."
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