Wales boss Chris Coleman has demanded no player "pull-outs" ahead of the Mexico clash in New York on 27 May.
It will be his first match in charge after taking a back seat for the
Gary Speed Memorial Match with Costa Rica.
And Coleman is insisting his top players commit to Wales as they build to the 2014 World Cup qualifiers.
"If guys are genuinely injured, if they physically or mentally shattered then that is a conversation, but I don't expect pull-outs," insisted Coleman.
The game against Mexico will be the first of two friendly matches before the World Cup qualifying campaign begins against Belgium in September with Wales facing Bosnia-Hercegovina on 14 August.
"I've picked a strong squad. We are not going there as an end of season game with a smile on our face," said Coleman.
"We are going there to get a result and a performance that is going to put us in a good way building up to the Bosnia then the Belgium game.
"It's a serious game for us. [I'm] thoroughly looking forward to it hence why I have picked a strong squad."
The Mexico game will be Wales' first since the 1-0 defeat at the hands of Costa Rica on 29 February - a game which marked Gary Speed
Coleman, who has selected
Craig Bellamy, Gareth Bale and Aaron Ramsey
in a 23-man squad, hopes that the lure of playing at the MetLife Stadium in New York will be a good incentive for his top players.
"We can say they have had long hard seasons some of them. They may want a rest, but then who wants to come and play for their country against one of the top teams in Mexico in a magnificent stadium?
"I went to look at it last month - it's one of the best I've seen. The facilities are absolutely wonderful and it's two games before we play Belgium."
Coleman believes Mexico, who are 20 in the
- 21 places above Wales - will be a useful test for his squad.
"[It's a] big test for us and a big test for Mexico also," he said.
"They are a good team. I watched them a lot in the World Cup in South Africa. Technically very good, tactically very sharp [with] quick players.
"They defend in numbers, they are patient with the ball and they are exciting going forward. So it's no fluke where they are in the world rankings. They are a good team but we are a good team.
"It will be a tough test for us. It will. But it 's not going to be a stroll in the park for them."
And Coleman expects to Manchester United striker Javier Hernandez will be in Mexico's team.
"He has had a quiet season because it's his second season and I think Alex has looked after him a, little physically because of the demands of the Premier League, but he is a smashing player," said the former Fulham boss.
"He has been pulled out of the Olympic squad as I understand, so I would imagine he would start against us."
Jason Brown (Aberdeen), Lewis Price (Crystal Palace), Rhys Taylor (Chelsea), Chris Gunter (Nottingham Forest), Neil Taylor (Swansea City), Sam Ricketts (Bolton Wanderers), Ashley Williams (Swansea City), Adam Matthews (Celtic), Neal Eardley (Blackpool), Darcy Blake (Cardiff City), Joe Allen (Swansea City), Aaron Ramsey (Arsenal), Andrew Crofts (Norwich City), David Vaughan (Sunderland), Joe Ledley (Celtic), Andy King (Leicester City), David Edwards (Wolverhampton Wanderers), Gareth Bale (Tottenham Hotspur), Craig Bellamy (Liverpool), Hal Robson-Kanu (Reading), Steve Morison (Norwich City), Simon Church (Reading), Sam Vokes (Wolverhampton Wanderers).
Owain Fon Williams (Tranmere Rovers), Adam Henley (Blackburn Rovers), Rhoys Wiggins (Charlton Athletic), Billy Bodin (Swindon Town), David Cotterill (Barnsley - released), Jermaine Easter (Crystal Palace).