Atletico Madrid will play Athletic Bilbao in an all-Spanish Europa League final after beating Valencia.
Valencia duo Sofiane Feghouli and Sergio Canales were denied by Atletico keeper Thibaut Courtois as they tried to erode the 4-2 first-leg deficit.
But Adrian Lopez chested down and half-volleyed in for Atletico to take the sting out of Valencia's challenge.
A late confrontation marred the match as Atletico's Tiago was red-carded for apparently slapping Roberto Soldado.
Atletico, now preparing for their second Europa League final in three years, beat Valencia in the last eight on the way to victory in the tournament in 2010.
Ultimately, it was Atletico's stirring first-leg performance, which they won 4-2, and superior finishing in front of goal which won them the tie as they gave their rivals too much to do in the return leg.
Did you know?
- Atletico's three games at the final venue of Bucharest have ended in one win, one draw and one loss.
- The last all-Spanish Uefa Cup final was when Sevilla beat Espanyol on penalties in 2007.
- Atletico coach Diego Simeone won the 1998 Uefa Cup with Inter Milan.
Valencia thought they had been given a lifeline courtesy of Ricardo Costa's 94th minute first-leg goal after being thoroughly outplayed.
They hoped the header would give them the impetus to turn the tie around, especially with the Mestalla crowd behind them.
Valencia certainly piled on the pressure as they gave little respite to their visitors after quickly building up a head of steam.
Unlike the first leg, the Mestalla outfit showed a dynamism and desire as Atletico clung on to their advantage thanks to on-loan Chelsea keeper Thibaut Courtois.
The 19-year-old Belgian dived low to his left to keep out a deflected Feghouli strike and kept out the rebounded shot from Jonas.
Soon afterwards, he watched Soldado volley high on the stretch from an Antonio Barragan cross.
The busy Courtois fended away a Sergio Canales angled drive before Atletico threatened to make Valencia pay for not turning their pressure into goals.
Arda Turan surged forward and crossed for Falcao, whose eyes opened up at a chance that quickly disappeared as he was narrowly beaten to the ball by Valencia keeper Diego Alves.
Atletico's defending was more assured after the break and Lopez struck a superb sweet strike into the top corner to deflate the home side.
The goal secured a 10th successive win in Europa League competition for Atletico but there was an negative note with Tiago's dismissal.
The ex-Chelsea midfielder appeared to have been unfairly punished for handball to give Valencia a penalty, which was the pre-cursor to an ugly melee between the two teams.
Tiago became embroiled in an altercation with Soldado and appeared to slap the Valencia striker as the Atletico midfielder lost his temper.
After the dust had settled, there was no spot-kick and Tiago was given his marching orders meaning he will miss the 9 May final in Bucharest, Romania.
Atletico Madrid coach Diego Simeone: "They had control of the game and pressed us, but we made a tactical change and in the second half we didn't have many problems.
"As the game wore on spaces opened up and that's when Adrian scored his great goal."
Live Text Commentary
Full Time The referee ends the match.90:00 +2:05
Jeremy Mathieu takes a shot. Diego Godin manages to make a clearance.90:00 +1:51
David Albelda takes a shot. Fernandez Gabi gets a block in.90:00 +0:41
Jorge Koke decides to take the corner short.89:45
The assistant referee signals for offside against Roberto Soldado. Thibaut Courtois restarts play with the free kick.89:24
Eduardo Salvio takes a shot. Save made by Carreira Diego Alves.88:27
Shot from 25 yards from Jeremy Mathieu. Joao Miranda gets a block in.87:47
The referee blows for offside. Diego Godin restarts play with the free kick.85:37
Foul by Eduardo Salvio on Ramos Jordi Alba, free kick awarded. Carreira Diego Alves takes the free kick.84:59
Direct free kick taken by Thibaut Courtois.84:59 Booking
Booking Aritz Aduriz receives a yellow card.84:51
Aritz Aduriz concedes a free kick for a foul on Torres Juanfran.84:18
Facundo Tino Costa takes a shot. Thibaut Courtois makes a save.83:11 Substitution
Substitution (Atletico Madrid) makes a substitution, with Jorge Koke coming on for Ribas Diego.80:35
Jeremy Mathieu takes a shot. Blocked by Fernandez Gabi. Outswinging corner taken left-footed by Facundo Tino Costa from the left by-line.78:53 Dismissal
Dismissal Cardoso Tiago is shown a red card.78:30 Booking
Booking Booking for Ramos Jordi Alba for dissent.78:10
Carreira Diego Alves restarts play with the free kick.78:10 Booking
Booking The referee shows Roberto Soldado a yellow card.76:27
Handball by Cardoso Tiago.
Outswinging corner taken by Facundo Tino Costa.73:40 Substitution
Substitution Arda Turan goes off and Eduardo Salvio comes on.72:40
Radamel Falcao takes a shot. Blocked by Miguel Ricardo Costa.71:32
Ribas Diego concedes a free kick for a foul on David Albelda. Carreira Diego Alves restarts play with the free kick.70:36
Facundo Tino Costa produces a left-footed shot from outside the penalty box and misses left.69:35
David Albelda challenges Ribas Diego unfairly and gives away a free kick. Ribas Diego takes the free kick.69:14
Foul by Jeremy Mathieu on Arda Turan, free kick awarded. Fernandez Gabi restarts play with the free kick.66:53
Free kick taken by Joao Miranda.66:53 Substitution
Substitution Facundo Tino Costa replaces Dani Parejo.66:53
Sofiane Feghouli concedes a free kick for a foul on Fernandez Gabi.65:36
Radamel Falcao concedes a free kick for a foul on Miguel Ricardo Costa. Miguel Ricardo Costa restarts play with the free kick.64:36
Radamel Falcao takes a shot. Carreira Diego Alves makes a save.63:01
The ball is delivered by Arda Turan, save by Carreira Diego Alves. Inswinging corner taken by Ribas Diego from the left by-line, save made by Carreira Diego Alves.61:38
The assistant referee signals for offside against Radamel Falcao. Indirect free kick taken by Miguel Ricardo Costa.59:31
Assist on the goal came from Ribas Diego.59:31 Goal scored
Goal! - Lopez Adrian - Valencia 0 - 1 Atl Madrid Lopez Adrian grabs a goal from just inside the area to the top left corner of the goal. Valencia 0 (2)-(5) 1 Atletico Madrid.57:50 Substitution
Substitution Sergio Canales leaves the field to be replaced by Jeremy Mathieu.56:10
Adil Rami restarts play with the free kick.56:10 Substitution
Substitution (Valencia) makes a substitution, with Aritz Aduriz coming on for Oliveira Jonas.56:10
Free kick awarded for an unfair challenge on Roberto Soldado by Joao Miranda.55:14
Cardoso Tiago fouled by David Albelda, the ref awards a free kick. Cardoso Tiago takes the free kick.54:36
Arda Turan concedes a free kick for a foul on Dani Parejo. Direct free kick taken by Dani Parejo.53:18
Corner taken by Dani Parejo from the left by-line to the near post, clearance by Cardoso Tiago.50:03
Dani Parejo decides to take a short corner.45:01
The game restarts for the second half.45:01 Substitution
Substitution (Atletico Madrid) makes a substitution, with Fernandez Gabi coming on for Mata Mario Suarez.45:00 +1:04 Half time
Half Time The half-time whistle blows.41:03
Free kick awarded for a foul by Antonio Barragan on Kasmirski Filipe Luis. Free kick taken by Thibaut Courtois.39:51
Corner from the left by-line taken by Dani Parejo, clearance by Lopez Adrian.39:35
Sergio Canales takes a shot. Save by Thibaut Courtois.35:14 Booking
Booking Thibaut Courtois goes into the book for time wasting.34:15
Sergio Canales takes a shot. Blocked by Joao Miranda. Sergio Canales takes the inswinging corner, Lopez Adrian makes a clearance.32:42
Joao Miranda fouled by Oliveira Jonas, the ref awards a free kick. Direct free kick taken by Joao Miranda.32:04
Sergio Canales has a headed effort at goal from deep inside the area missing to the left of the target.30:14
Free kick awarded for an unfair challenge on Diego Godin by Oliveira Jonas. Thibaut Courtois takes the free kick.28:40
Sofiane Feghouli has shot on goal from a long way out that goes wide left.27:31
Inswinging corner taken right-footed by Dani Parejo from the left by-line, Diego Godin fouled by Adil Rami, the ref awards a free kick. Thibaut Courtois takes the free kick.25:50
Free kick awarded for a foul by Cardoso Tiago on Oliveira Jonas. Direct free kick taken by David Albelda.25:33
The official flags Roberto Soldado offside. Thibaut Courtois takes the indirect free kick.23:11
Roberto Soldado takes a shot. Save by Thibaut Courtois.21:51
Shot from deep inside the area by Roberto Soldado clears the bar.21:39
Ribas Diego gives away a free kick for an unfair challenge on David Albelda. David Albelda takes the free kick.21:08
Effort from just outside the area by Sofiane Feghouli goes over the bar.19:40
Inswinging corner taken from the left by-line by Dani Parejo, Sofiane Feghouli takes a shot. Thibaut Courtois makes a save. Oliveira Jonas takes a shot. Save by Thibaut Courtois. Sergio Canales takes a short corner.17:04
Corner taken left-footed by Sergio Canales to the near post, Arda Turan delivers the ball.13:30
Effort on goal by Arda Turan from long range goes harmlessly over the bar.7:48
Foul by Roberto Soldado on Kasmirski Filipe Luis, free kick awarded. Thibaut Courtois restarts play with the free kick.6:11
Free kick awarded for a foul by Adil Rami on Thibaut Courtois. Free kick taken by Thibaut Courtois.5:40
Diego Godin gives away a free kick for an unfair challenge on Roberto Soldado. Sergio Canales crosses the ball in from the free kick, save by Thibaut Courtois.5:11
Ribas Diego takes a shot. Carreira Diego Alves makes a comfortable save.4:04
Radamel Falcao fouled by Ramos Jordi Alba, the ref awards a free kick. Direct free kick taken by Torres Juanfran.2:58
Free kick awarded for an unfair challenge on Sofiane Feghouli by Cardoso Tiago. Dani Parejo restarts play with the free kick.0:00
The referee starts the match.
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