Asa Hall scored twice to give Oxford victory at Accrington and lift the U's up to sixth position in League Two.
The hosts nearly went ahead but defender Jake Wright cleared Jamie Devitt's volley off the goal-line.
Hall grabbed his first goal two minutes later when Accrington failed to clear and he collected a loose ball and smashed a low shot home from 12 yards.
Bobby Grant and Padraig Amond missed chances for an equaliser, before Hall headed in from James Constable's cross.
VIEWS FROM THE DRESSING ROOM
Oxford United manager Chris Wilder told BBC Radio Oxford:
"I had a bit of a bark at the players at half-time because I thought we could do a lot more, and when we did we scored at a decent time.
"It's not easy coming here, even though they had a few injury problems at the back, the mentality of the players is such they always give it a go and they're a dangerous outfit.
"The result is the main event, and to get four points out of six from two difficult away games is a real good effort. Goals change games, the first was very well-timed and the second was a great goal."
Kevin McIntyre produces a cross, Header from deep inside the penalty area by Peter Murphy goes harmlessly over the crossbar.
Jake Wright gives away a free kick for an unfair challenge on Padraig Amond. Direct free kick taken by Jamie Devitt.
Substitution Cristian Montano leaves the field to be replaced by Scott Rendell.
Luke Joyce crosses the ball, Headed effort from inside the area by Padraig Amond misses to the right of the target.
Substitution Oli Johnson leaves the field to be replaced by Anthony Tonkin.
Booking Peter Murphy receives a caution.
James Constable fouled by Peter Murphy, the ref awards a free kick. Direct free kick taken by Liam Davis.
Substitution Ian Craney is brought on as a substitute for Bobby Grant.
Foul by Liam Davis on Padraig Amond, free kick awarded. Free kick taken by Craig Lindfield.
Cristian Montano takes a shot. Save made by Lee Nicholls.
The assist for the goal came from Cristian Montano.
Clearance by Peter Murphy.
Substitution Charlie Barnett goes off and Ryan Hopper comes on.
Substitution Harry Worley goes off and Andrew Whing comes on.
Corner taken left-footed by Asa Hall,
Assist by Liam Davis.
72:52 Goal scored
Goal - Asa Hall - Accrington 0 - 2 Oxford Asa Hall grabs a headed goal from inside the area. Accrington Stanley 0-2 Oxford Utd.
Clearance made by Peter Murphy.
Substitution Charlie Barnett goes off and Ryan Hopper comes on.
Substitution Andrew Whing joins the action as a substitute, replacing Harry Worley.
Inswinging corner taken left-footed by Asa Hall from the right by-line,
Substitution (Accrington Stanley) makes a substitution, with Will Hatfield coming on for Micah Evans.
Cristian Montano challenges Micah Evans unfairly and gives away a free kick. Direct free kick taken by Micah Evans.
The referee blows for offside against James Constable. Lee Nicholls takes the free kick.
Bobby Grant fouled by Adam Chapman, the ref awards a free kick. Direct free kick taken by Luke Joyce.
Corner from right by-line taken by Bobby Grant.
Inswinging corner taken right-footed by Craig Lindfield from the left by-line to the near post.
Micah Evans takes a shot. Liam Davis gets a block in.
Free kick awarded for an unfair challenge on Peter Murphy by James Constable. Free kick taken by Lee Nicholls.
Effort on goal by Bobby Grant from just inside the area clears the bar.
Padraig Amond takes a shot. Ryan Clarke makes a save.
Asa Hall takes a shot. Save by Lee Nicholls. Outswinging corner taken from the left by-line by Adam Chapman.
Micah Evans concedes a free kick for a foul on Damian Batt. Peter Leven takes the direct free kick.
Corner taken left-footed by Peter Leven from the right by-line, Luke Joyce manages to make a clearance. Corner taken left-footed by Peter Leven from the right by-line, Michael Liddle makes a clearance.
Unfair challenge on Asa Hall by Charlie Barnett results in a free kick. Harry Worley restarts play with the free kick.
The second half begins.
45:00 +1:10 Half time
Half Time The referee blows for half time.
Free kick awarded for a foul by Adam Chapman on Jamie Devitt. Jamie Devitt crosses the ball in from the free kick.
Outswinging corner taken by Jamie Devitt. Padraig Amond is flagged offside by the assistant referee. Indirect free kick taken by Ryan Clarke.
Bobby Grant takes a shot. Ryan Clarke makes a save.
41:35 Goal scored
Goal - Asa Hall - Accrington 0 - 1 Oxford Asa Hall scores a goal from just outside the penalty box to the bottom left corner of the goal. Accrington Stanley 0-1 Oxford Utd.
Free kick awarded for a foul by Charlie Barnett on Peter Leven. Direct free kick taken by Harry Worley.
Inswinging corner taken by Jamie Devitt from the left by-line played to the near post, James Constable makes a clearance.
Jamie Devitt takes a shot. Clearance by Harry Worley. Corner taken by Jamie Devitt, clearance by Harry Worley. Inswinging corner taken from the left by-line by Jamie Devitt.
Micah Evans takes a shot. Blocked by Adam Chapman.
Corner taken by Adam Chapman, save by Lee Nicholls.
James Constable concedes a free kick for a foul on Luke Joyce. Lee Nicholls restarts play with the free kick.
The referee penalises James Constable for handball. Lee Nicholls restarts play with the free kick.
Free kick awarded for a foul by Charlie Barnett on Cristian Montano. Direct free kick taken by Adam Chapman.
Kevin McIntyre produces a right-footed shot from outside the box and misses left.
Free kick awarded for an unfair challenge on Peter Murphy by Peter Leven. Indirect free kick taken by Lee Nicholls.
Effort on goal by Charlie Barnett from 35 yards cleared the target.
James Constable is flagged offside by the assistant referee. Indirect free kick taken by Peter Murphy.
Booking James Constable receives a yellow card.
Foul by James Constable on Michael Liddle, free kick awarded. Lee Nicholls takes the indirect free kick.
Cristian Montano takes a shot.
The offside flag is raised against James Constable. Lee Nicholls takes the free kick.
The official flags James Constable offside. Michael Liddle takes the free kick.
Inswinging corner taken from the right by-line by Peter Leven, Headed effort from inside the area by Asa Hall misses to the right of the target.
The referee starts the match.
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