Paul Cook saw his Accrington side thrashed by Plymouth in his first game in charge.
On-loan Burnley striker Alex MacDonald put the visitors ahead, finishing neatly after exchanging passes with Nick Chadwick on the edge of the area.
MacDonald added a second after Chadwick's long range effort was parried by home keeper Ian Dunbavin.
Darren Purse headed in a third from Paul Wotton's free kick, and substitute Luke Daley fired in the fourth.
VIEWS FROM THE DRESSING ROOM
Plymouth Argyle manager Carl Fletcher told BBC Radio Devon:
"Towards the end of the game when you're a few goals up it can be difficult, you could see the lads didn't want to concede.
"Away wins are so hard to come by in any division, so it's nice to get one.
"We weren't one hundred per cent sure because they've got a new manager in, but we were solid, we scored goals and we got a clean sheet.
"There's always things you can improve on. We won't get carried away with it, we'll go back to work on Monday and get on with it."
Accrington Stanley 25 Dunbavin 03 Winnard 05 Nsiala 12 Murphy Booked 14 McIntyre 08 Barnett (Devitt - 52' ) 11 Joyce 19 Evans (Willis - 74' ) 27 Hughes 07 Lindfield Booked 21 Smith (Amond - 59' ) Substitutes 01 Murdoch 02 Coid 18 Willis 17 Devitt 23 Amond Plymouth Argyle 01 Larrieu 05 Purse 14 Bhasera 22 Blanchard 28 Bignot 15 Young 19 Wotton 20 Hourihane 32 MacDonald Booked (Daley - 86' ) 29 Chadwick Booked (Tsoumou - 77' ) 31 Hemmings (Walton - 68' ) Substitutes 02 Berry 07 Daley 08 Walton 09 Tsoumou 27 Lecointe
Ref: Mark Heywood