It was a blistering opening by Tottenham, whose fans were still affectionately singing Redknapp's name when Adebayor exchanged passes with Gareth Bale on the edge of the box and set up the unmarked Assou-Ekotto for the simplest of tap-ins at the back post.
Redknapp had barely retaken his seat before he was up celebrating again after
January signing Saha
darted into the box and volleyed Adebayor's right-wing cross past Newcastle keeper Tim Krul from 10 yards to make it 2-0.
And Saha, who scored two goals in 20 games for Everton this season prior to his move to north London, made it two in 20 minutes at White Hart Lane for Spurs with another cool finish.
Assou-Ekotto started the move with a precise pass into Luka Modric who skipped into the box before finding Adebayor who in turn nudged the ball into the path of Saha and the striker nonchalantly side-footed in.
A shell-shocked Newcastle did not help themselves with numerous passes going astray and even when they did manage to forage forward, luck was against them - Demba Ba tested Spurs keeper Brad Friedel with a 20-yard free-kick but referee Andre Marriner missed the American's fingertip save and gave a goal-kick.
Tottenham looked likely to score every time they ventured over the halfway line and the fourth came after just 34 minutes when Kranjcar, who had earlier blasted an 18-yard effort over the bar, rolled in his first goal of the season from 15 yards after Krul kept out Adebayor's low shot.
Pardew admits Newcastle tactics were wrong against Tottenham
The striker swivelled and volleyed on the turn after Saha had flicked on Assou-Ekotto's cross.
It proved to be Saha's last meaningful contribution as Redknapp replaced him and Bale with Aaron Lennon and Jermain Defoe, both of whom wreaked more havoc with their pace.
However, it was Newcastle who should have scored the sixth goal of the game. Danny Guthrie's teasing ball into box was met by Ba but his powerful header was well saved by Friedel and, with the goal at his mercy, Dan Gosling scooped the rebound over the bar.
Adebayor fired inches wide and cleared the crossbar with another effort while Krul kept out a fiercely struck Modric effort as Tottenham pressed to the end.
Full Time The referee signals the end of the game.
Jonas Gutierrez takes a shot. Blocked by Michael Dawson.
The offside flag is raised against Emmanuel Adebayor. Danny Simpson takes the free kick.
The referee blows for offside against Jermain Defoe. Tim Krul restarts play with the free kick.
Free kick awarded for an unfair challenge on Ryan Nelsen by Demba Ba. Free kick taken by Ryan Nelsen.
Unfair challenge on Emmanuel Adebayor by Danny Simpson results in a free kick. Benoit Assou-Ekotto takes the direct free kick.
Substitution Danny Guthrie leaves the field to be replaced by Peter Lovenkrands.
Effort on goal by Emmanuel Adebayor from just inside the area clears the bar.
Luka Modric takes a inswinging corner.
Inswinging corner taken by Luka Modric from the left by-line.
Jermain Defoe fouled by Fabricio Coloccini, the ref awards a free kick. Luka Modric crosses the ball from the free kick right-footed from right wing, Danny Simpson makes a clearance.
Luka Modric takes a shot. Save by Tim Krul.
Effort from deep inside the area by Emmanuel Adebayor misses to the left of the target.
Shot from deep inside the area by Dan Gosling clears the crossbar.
Demba Ba takes a shot. Save made by Brad Friedel.
Danny Guthrie takes the free kick.
Substitution Ryan Nelsen comes on in place of Ledley King.
Scott Parker challenges Danny Guthrie unfairly and gives away a free kick.
The ball is delivered by Kyle Walker, clearance made by Danny Simpson.
Foul by Danny Simpson on Scott Parker, free kick awarded. Benoit Assou-Ekotto takes the free kick.
Luka Modric restarts play with the free kick.
Booking Dan Gosling is shown a yellow card.
Dan Gosling concedes a free kick for a foul on Aaron Lennon.
Substitution Dan Gosling is brought on as a substitute for Papiss Cisse.
Substitution Jermain Defoe is brought on as a substitute for Louis Saha.
Substitution Aaron Lennon is brought on as a substitute for Gareth Bale.
Shot from just outside the box by Gareth Bale goes over the bar.
Louis Saha provided the assist for the goal.
63:58 Goal scored
Goal! - Emmanuel Adebayor - Tottenham 5 - 0 Newcastle A goal is scored by Emmanuel Adebayor from inside the box to the bottom left corner of the goal. Tottenham 5-0 Newcastle.
The ball is crossed by Jonas Gutierrez, Kyle Walker manages to make a clearance.
Emmanuel Adebayor has an effort at goal from deep inside the area missing to the right of the goal.
Unfair challenge on Luka Modric by Davide Santon results in a free kick. Free kick taken by Niko Kranjcar.
Free kick awarded for an unfair challenge on Scott Parker by Danny Simpson. Direct free kick taken by Luka Modric.
The second half has started.
Substitution Gabriel Obertan leaves the field to be replaced by Shane Ferguson.
45:00 +2:59 Half time
Half Time The players leave the pitch at half time.
Niko Kranjcar takes a shot. Blocked by Fabricio Coloccini. The offside flag is raised against Emmanuel Adebayor. Tim Krul restarts play with the free kick.
Scott Parker fouled by Fabricio Coloccini, the ref awards a free kick. Emmanuel Adebayor restarts play with the free kick. Benoit Assou-Ekotto has an effort at goal from just outside the area which goes wide of the left-hand post.
Luka Modric takes a shot. Fabricio Coloccini gets a block in.
Fabricio Coloccini challenges Gareth Bale unfairly and gives away a free kick. Scott Parker takes the free kick.
Inswinging corner taken right-footed by Luka Modric.
Corner taken by Luka Modric from the right by-line played to the near post, clearance by Danny Simpson.
Effort from the edge of the area by Louis Saha goes wide of the left-hand upright.
Danny Guthrie takes a inswinging corner from the left by-line to the near post.
Indirect free kick taken by Danny Guthrie.
Booking Kyle Walker goes into the book for unsporting behaviour.
Free kick awarded for a foul by Kyle Walker on James Perch.
Demba Ba takes a shot. Save by Brad Friedel.
Kyle Walker sends in a cross, clearance made by Davide Santon.
Free kick awarded for an unfair challenge on Jonas Gutierrez by Scott Parker. Fabricio Coloccini has an effort direct from the free kick.
Outswinging corner taken right-footed by Danny Guthrie, clearance made by Gareth Bale.
The ball is sent over by Davide Santon, Ledley King makes a clearance.
The assist for the goal came from Emmanuel Adebayor.
33:26 Goal scored
Goal! - Niko Kranjcar - Tottenham 4 - 0 Newcastle Niko Kranjcar fires in a goal from inside the penalty area to the bottom left corner of the goal. Tottenham 4-0 Newcastle.
Emmanuel Adebayor takes a shot. Save by Tim Krul.
Free kick awarded for an unfair challenge on Demba Ba by Michael Dawson. Danny Guthrie takes the free kick.
Emmanuel Adebayor challenges Jonas Gutierrez unfairly and gives away a free kick. Demba Ba takes the indirect free kick.
Centre by Jonas Gutierrez, clearance made by Ledley King.
Demba Ba has an effort direct from the free kick.
Booking Scott Parker shown a yellow card.
Scott Parker concedes a free kick for a foul on Demba Ba.
Emmanuel Adebayor produces a left-footed shot from just outside the box that misses to the right of the net.
The assist for the goal came from Emmanuel Adebayor.
19:30 Goal scored
Goal! - Louis Saha - Tottenham 3 - 0 Newcastle A goal is scored by Louis Saha from deep inside the penalty area to the bottom left corner of the goal. Tottenham 3-0 Newcastle.
Headed effort from deep inside the area by Demba Ba misses to the right of the target.
Luka Modric takes a shot. James Perch gets a block in.
Gareth Bale produces a cross, Danny Simpson makes a clearance. Benoit Assou-Ekotto crosses the ball, clearance by Davide Santon.
Niko Kranjcar produces a right-footed shot from just outside the area that goes harmlessly over the target.
Corner taken right-footed by Danny Guthrie to the near post, clearance made by Michael Dawson.
The ball is sent over by Papiss Cisse, clearance made by Kyle Walker.
Scott Parker challenges Jonas Gutierrez unfairly and gives away a free kick. Tim Krul takes the free kick.
The ball is delivered by Kyle Walker, clearance by Davide Santon.
The referee blows for offside. Mike Williamson restarts play with the free kick.
Emmanuel Adebayor provided the assist for the goal.
5:30 Goal scored
Goal! - Louis Saha - Tottenham 2 - 0 Newcastle A goal is scored by Louis Saha from inside the box high into the middle of the goal. Tottenham 2-0 Newcastle.
The offside flag is raised against Emmanuel Adebayor. Free kick taken by Tim Krul.
Assist by Emmanuel Adebayor.
3:05 Goal scored
Goal! - Benoit Assou-Ekotto - Tottenham 1 - 0 Newcastle Benoit Assou-Ekotto gets on the score sheet with a goal from close range to the top right corner of the goal. Tottenham 1-0 Newcastle.
The ball is swung over by Jonas Gutierrez, clearance made by Gareth Bale.
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