"It is a massive game for both clubs. There is a tremendous profile on it," said Ferguson.
"I am confident. We want to talk about the game of football. It is something you want to look forward to. That is what I intend to do.
Best of enemies
Liverpool and Manchester United have been drawn together in the FA Cup on 10 occasions, with United coming out on top seven times, including the finals in 1977 and 1996
"Our fans were terrific there this season. The stewards have a difficult enough job as it is. We should be helping."
Despite his warning, Ferguson wants United's supporters to be "positive, witty and loud".
Liverpool managing director Ian Ayre, meanwhile, wants "rivalry not hatred" with Manchester United.
Ayre said: "We mustn't detract from fans chanting and singing at each other but it needs to be a rivalry thing rather than a hatred thing."
There have been fears that the bitter relationship between the two sets of fans could reach new levels after the Suarez suspension, resulting in an ugly atmosphere at the match.
Following the ruling on Suarez, who could return from his ban at Old Trafford on 11 February, the Football Association called on the two clubs to get together to smooth relations before the Cup tie.
Ayre is also hoping that Saturday's clash produces a memorable football match in a lively atmosphere.
He told BBC Radio Merseyside: "It is the FA Cup, a great competition in English football and one we have a great history in and we want that to be what everyone focuses on.
"We have massive rivalry with Manchester United but those who are respectful also have respect for them because they are a great footballing side and team and, like us, they have been very successful.
"It is about a great spirit and a match between two great teams and it is certainly not hatred - there is no place for hatred in football.
"The banter on the terraces is great, both managers feel that as do the players. Far from trying to neutralise it we want our fans to be as vocal as they normally are against Manchester United.
"We definitely don't want to detract from that but both clubs have histories which have some things in people don't want to hear being sung about and so we want the fans to get behind the team, have a bit of fun and enjoy the game."
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