Gary Alexander grabbed a hat-trick as Brentford won for the first time in eight matches to send Wycombe bottom.
Alexander scored with two headers from Jake Bidwell crosses either side of a close-range finish from Sam Saunders.
Dave Winfield headed in Grant Basey's free-kick but Toumani Diagouraga restored Brentford's three-goal lead, latching on to Marcus Bean's cross.
Ben Strevens converted Joel Grant's cut-back for 4-2 but Alexander sealed the victory with a stunning volley.
Alexander has now scored five goals in two matches after he grabbed a brace in the Bees' 3-2 defeat against Huddersfield on 21 January.
VIEWS FROM THE DRESSING ROOM
Brentford manager Uwe Rosler told BBC London 94.9:
"We wanted to play a different way against them and I thought the tactics were spot on - the players executed the game plan perfectly.
"I'm very happy that the players had a break today as we've had an number of good performances and didn't get the rewards.
"We had a lot of up and downs but more ups than downs so I'm very happy for the players."
Brentford 01 Lee 14 Logan 24 Bidwell 25 Dean Booked 32 Legge 04 Bean 07 Saunders (Weston - 80' ) 08 Douglas 20 Diagouraga Booked 09 Donaldson 29 Alexander Substitutes 31 Moore 05 Eger 11 Weston 18 McGinn 19 Forrester Wycombe Wanderers 01 Bull 02 Foster 03 Laing 05 Winfield Booked 15 Basey 10 Bloomfield 16 Harper 17 Grant 18 Lewis (Ainsworth - 46' ) 12 Strevens 20 Beavon Substitutes 19 McCoy 07 Ainsworth 26 Kewley-Graham 09 Rendell 29 McClure
Ref: Mark Heywood