Preston slumped to defeat against Leyton Orient in Graham Westley's first game in charge.
The home side stuggled in the first half with debutants Andy Procter, Chris Holroyd and Jamie McAllister failing to make an impact on the game.
Orient took the lead after the break with Marc Laird curling a shot past Thorsten Stuckmann from 20 yards.
Jimmy Smith added the visitors' second from close range after collecting Dean Cox's looping cross.
VIEWS FROM THE DRESSING ROOM
Leyton Orient Manager Russell Slade told BBC London 94.9:
"The only disappointing thing from the first half was we didn't get a goal but I'm delighted with the second half.
"Today we put in a really good away performance and a really good professional performance.
"It is our fifth win of the season and it's put us halfway up the table. If we can put the run together like we did last season then who knows where it will take us."
Preston North End 01 Stuckmann 05 Carlisle Booked 06 Morgan 12 McLean (Gray - 84' ) 35 McAllister (Tsoumou - 81' ) 08 Coutts 17 Parry 38 Procter 09 Proctor 34 Jervis (Nicholson - 37' ) 37 Holroyd Substitutes 25 Arestidou 02 Gray 10 Nicholson 15 Barton 11 Tsoumou Leyton Orient 12 Butcher 05 Cuthbert 06 Forbes 26 Leacock 07 Cox 14 McSweeney 16 Spring 17 Laird 20 Smith 09 Lisbie (Tehoue - 89' ) 39 Mooney Substitutes 01 Jones 02 Ben Youssef 15 Porter 10 Cureton 18 Tehoue