Kevin Pilkington's own goal gave Southport a share of the points against high-flying Luton.
Tony Gray put the hosts ahead with a 25-yard drive into the top corner, before Vinny Mukendi made it 2-0 with a low shot from 18 yards.
Danny Crow pulled a goal back with a header before Adam Watkins equalised with a shot from the edge of the area.
Aaron O'Connor looked to have completed the comeback from 18 yards, but Pilkington gave Southport a point.
VIEWS FROM THE DRESSING ROOM
Southport manager Liam Watson told BBC Radio Merseyside:
"We went into a 2-0 lead, and I don't know if that flattered us somewhat because Luton were playing some good football.
"Even when we were 2-2 at half time, I told the players they'd put a shift in and we looked like a good team.
"We've come away with a point and a point against Luton is always a good one."
Luton Town manager Gary Brabin told BBC Three Counties Radio:
"We're obviously disappointed we've dropped two points, that's a real kick in the teeth.
"Under normal circumstances coming here and getting a draw in better conditions wouldn't have been a bad result.
"When we're playing catch-up the way we are at the moment, it's disappointing.
"I thought we carved out two really great goals and they got us back in the game."
Live Text Commentary
Full Time The referee blows for the end of the match.90:00 +2:52
Tony Gray is caught offside. Free kick taken by Kevin Pilkington.90:00 +2:15
Amari Morgan-Smith challenges Andy Owens unfairly and gives away a free kick. Tony McMillan takes the indirect free kick.90:00 +1:31
Danny Crow takes a shot. Save by Tony McMillan.89:46
Shot from just outside the box by Tony Gray goes over the target.88:27
Karl Ledsham takes a inswinging corner to the near post.88:22
Centre by Shaun Whalley, clearance by Greg Taylor.86:11
Steve Akrigg concedes a free kick for a foul on Kevin Pilkington. Indirect free kick taken by Kevin Pilkington.85:40
Corner taken by Shaun Whalley, Kevin Pilkington makes a save.83:19
Shaun Whalley produces a right-footed shot from just outside the box that goes wide right of the goal.82:44
Unfair challenge on Greg Taylor by James Ellison results in a free kick. Greg Taylor restarts play with the free kick.81:15
Corner from the right by-line taken by Karl Ledsham, Shot from deep inside the area by Russell Benjamin clears the bar.81:03
Shaun Whalley takes a shot. Save by Kevin Pilkington.79:52
Amari Morgan-Smith produces a cross, Headed effort from deep inside the area by Danny Crow misses to the right of the target.78:13
The ball is delivered by Shaun Whalley, clearance by Janos Kovacs. Corner taken left-footed by Karl Ledsham, James Ellison produces a headed effort from deep inside the six-yard box which goes wide of the right-hand upright.75:51
Unfair challenge on Alex Lawless by Tony Gray results in a free kick. Greg Taylor takes the indirect free kick.75:27
Inswinging corner taken right-footed by Adam Watkins, clearance made by Tony McMillan.75:04
Jake Howells takes a shot. Blocked by Andy Owens.74:55
Jake Howells sends in a cross, Steve Akrigg manages to make a clearance.74:10 Substitution
Substitution Vinny Mukendi goes off and James Ellison comes on.
Russell Benjamin produces a right-footed shot from just outside the box that misses to the right of the target.73:00
Alex Lawless takes a shot. Steve Akrigg gets a block in.72:15
Free kick awarded for a foul by Simon Grand on Jake Howells. Indirect free kick taken by Daniel Gleeson.72:00
The ball is sent over by Greg Taylor, Tony McMillan makes a save.69:28
Vinny Mukendi takes a shot. Blocked by George Pilkington. Corner taken by Karl Ledsham from the right by-line to the near post.67:12
Jake Howells gives away a free kick for an unfair challenge on Simon Grand. Tony McMillan takes the indirect free kick.66:02
Shaun Whalley has a shot on goal from outside the area which misses right.65:33
Danny Crow takes a shot. Save by Tony McMillan.63:36
Shot from just outside the box by Aaron O'Connor misses to the right of the goal.63:22
Jake Howells takes a shot. Andrew Parry gets a block in.62:10 Substitution
Substitution Amari Morgan-Smith is brought on as a substitute for John Kissock.59:48
Shaun Whalley takes a shot. Blocked by Alex Lawless.58:55 Goal scored
Goal! - Kevin Pilkington - Southport 3 - 3 Luton Kevin Pilkington scores an own goal from 6 yards. Southport 3-3 Luton.57:27
Tony Gray fouled by Greg Taylor, the ref awards a free kick. Strike comes in from Tony Gray from the free kick.55:47
Corner taken by Shaun Whalley played to the near post, clearance made by Danny Crow.54:11
Aaron O'Connor has shot on goal from just outside the box which goes wide of the right-hand upright.53:40 Booking
Booking Russell Benjamin is booked.53:06
George Pilkington fouled by Russell Benjamin, the ref awards a free kick. Kevin Pilkington restarts play with the free kick.51:59
Karl Ledsham takes a shot. Alex Lawless gets a block in. Corner from left by-line taken by Shaun Whalley.50:10
Simon Grand has an effort at goal from the edge of the box that misses to the right of the target.48:50
Unfair challenge on Steve Akrigg by Jake Howells results in a free kick. Tony McMillan takes the free kick.48:05
Karl Ledsham takes a shot. Kevin Pilkington makes a fantastic save.47:16
Vinny Mukendi takes a shot. Save made by Kevin Pilkington.46:38 Goal scored
Goal! - Aaron O'Connor - Southport 2 - 3 Luton Aaron O'Connor finds the net with a goal from the edge of the area low into the middle of the goal. Southport 2-3 Luton.46:14
Foul by Shaun Whalley on Daniel Gleeson, free kick awarded. Kevin Pilkington takes the indirect free kick.45:01
The referee starts the second half.45:00 +7:20 Half time
Half Time The half-time whistle blows.45:00 +6:57
Short corner taken by Adam Watkins from the left by-line.45:00 +6:26
Karl Ledsham challenges Jake Howells unfairly and gives away a free kick. The free kick is delivered left-footed by Jake Howells from right wing, save by Tony McMillan.45:00 +5:13
Aaron O'Connor crosses the ball.45:00 +3:11 Booking
Booking Booking for Adam Watkins for unsporting behaviour.45:00 +2:36
Danny Crow provided the assist for the goal.45:00 +2:36 Goal scored
Goal! - Adam Watkins - Southport 2 - 2 Luton Adam Watkins grabs a goal from the edge of the penalty area to the top right corner of the goal. Southport 2-2 Luton.43:32 Substitution
Substitution Russell Benjamin is brought on as a substitute for Chris Lever.43:32
Free kick awarded for an unfair challenge on Chris Lever by Aaron O'Connor. Indirect free kick taken by Simon Grand.42:43
John Kissock takes a shot. Tony McMillan makes a comfortable save.41:32
Vinny Mukendi gives away a free kick for an unfair challenge on Daniel Gleeson. Kevin Pilkington restarts play with the free kick.38:55
Greg Taylor provided the assist for the goal.38:55 Goal scored
Goal! - Danny Crow - Southport 2 - 1 Luton Danny Crow finds the net with a headed goal from inside the six-yard box. Southport 2-1 Luton.35:33
Jake Howells produces a cross, Tony McMillan makes a clearance.35:09
The offside flag is raised against Vinny Mukendi. Adam Watkins restarts play with the free kick.33:41
Andy Owens has a headed effort at goal from just inside the box that misses to the right of the goal.32:06 Goal scored
Goal! - Vinny Mukendi - Southport 2 - 0 Luton Vinny Mukendi fires in a goal from the edge of the penalty box to the bottom right corner of the goal. Southport 2-0 Luton.29:06
Karl Ledsham challenges Greg Taylor unfairly and gives away a free kick. Alex Lawless takes the free kick.27:13
Karl Ledsham challenges Adam Watkins unfairly and gives away a free kick. Free kick taken by Kevin Pilkington.25:42
Chris Lever challenges Aaron O'Connor unfairly and gives away a free kick. George Pilkington restarts play with the free kick.22:46
Unfair challenge on Andy Owens by Daniel Gleeson results in a free kick. Shaun Whalley delivers the ball from the free kick right-footed from left wing, save by Kevin Pilkington.18:27
The referee blows for offside against Danny Crow. Indirect free kick taken by Tony McMillan.14:15
Adam Watkins handles the ball and concedes a free kick. Tony McMillan restarts play with the free kick.10:31
Vinny Mukendi concedes a free kick for a foul on John Kissock. George Pilkington takes the free kick.9:02
Assist by Shaun Whalley.9:02 Goal scored
Goal! - Tony Gray - Southport 1 - 0 Luton A goal is scored by Tony Gray from outside the box high into the middle of the goal. Southport 1-0 Luton.7:18
Corner from right by-line taken by Karl Ledsham.5:04
Jake Howells produces a left-footed shot from just outside the box that misses to the right of the goal.4:36
Jake Howells decides to take the corner short.3:34
Adam Watkins takes a shot. Save made by Tony McMillan.0:00
The game kicks-off.
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