Matt Phillips scored a hat-trick as Blackpool eased past non-league neighbours Fleetwood at Highbury.
Lomana LuaLua opened the scoring for the visitors midway through the first half before Phillips and Tom Ince extended the lead after the break.
Jamie Vardy, who was a thorn in Blackpool's side, scored in the 70th minute to give Fleetwood hope.
However, Phillips struck twice more to deny the Cod Army, who gave a good account of themselves.
Phillips's second hat-trick in four games shattered Blue Square Bet Premier Fleetwood's hopes of an upset.
This tie was billed as the Fylde Coast derby, with around seven miles of tram track separating the two clubs, while Fleetwood's manager Micky Mellon had spent three years of his playing career at Blackpool.
DID YOU KNOW?
Fleetwood chairman Andy Pilley is a Blackpool fan
But Blackpool never looked back once LuaLua latched on to a through ball from Bob Harris before chipping a delightful opener over keeper Scott Davies in the 24th minute.
Phillips, who has now scored seven in four games after returning from a loan spell at Sheffield United earlier this season, doubled the Championship club's lead in the 47th minute with a delightful curling effort.
Yet this was not the one-sided tie the scoreline suggests.
Stand-in Blackpool keeper Mark Howard produced fine stops to deny Vardy, Peter Till and Andrew Mangan.
Even after Phillips had doubled the lead Varney flashed a header on to the roof of the net.
But Ince swept home Blackpool's third from Neal Eardley's right-wing cross in the 55th minute before Varney was finally rewarded for his efforts when he finished low past Howard.
Phillips hit the post from long range in the 75th minute, but netted his second two minutes later after LuaLua's effort was blocked, then completed his hat-trick nine minutes from time.
Fleetwood manager Micky Mellon:
"Anyone who saw it would have to admit that out of six chances Blackpool have taken five and that is the difference between levels.
"Some of the football we played was absolutely superb but we got punished every time Blackpool went forward. Some of their finishing was absolutely top-drawer and we're not used to that at this level."
Blackpool manager Ian Holloway:
"People will be looking at Matt Phillips now but we've got him and if you're a top five club, come and try and offer a lot of money for him.
"Why not sit and play in a team instead of rotting in someone's reserves and never getting a look in?
"At the end of the day we've got in a situation where we don't have to sell anyone.
"That was probably the biggest banana skin I've had in my life and we've managed to come out in a no-win situation and play well.
"Thank God we had the quality of our finishing because that was one hell of a game of football."
Live Text Commentary
Full Time The referee brings the game to a close.90:00 +2:55
A cross is delivered by Robert Harris.90:00 +1:53
The ball is crossed by Neal Eardley.86:26
A cross is delivered by Robert Harris, save by Scott Davies.85:38
Sean Clancy produces a cross, Neal Eardley gets a block in.84:34
Ludovic Sylvestre takes a short corner.84:26
Chris Basham takes a shot. Save made by Scott Davies.84:09
Short corner taken by Ludovic Sylvestre.83:28 Substitution
Substitution (Blackpool) makes a substitution, with Kevin Phillips coming on for Martinez Angel.82:43
The ball is delivered by Sean Clancy, blocked by Chris Basham.81:32 Substitution
Substitution Jamie Milligan goes off and Sean Clancy comes on.81:10 Substitution
Substitution Lomana Tresor LuaLua leaves the field to be replaced by Gary Taylor-Fletcher.80:05
Assist by Neal Eardley.80:05 Goal scored
Goal! - Matt Phillips - Fleetwood 1 - 5 Blackpool Matt Phillips fires in a goal from inside the penalty area to the bottom right corner of the goal. Fleetwood Town 1-5 Blackpool.77:34
Ludovic Sylvestre takes a short corner.76:08
Assist on the goal came from Thomas Ince.76:08 Goal scored
Goal! - Matt Phillips - Fleetwood 1 - 4 Blackpool Matt Phillips gets on the score sheet with a goal from inside the box to the bottom right corner of the goal. Fleetwood Town 1-4 Blackpool.76:06
Thomas Ince takes a shot. Scott Davies makes a save.75:19
Foul by Danny Wilson on Jamie Vardy, free kick awarded. Free kick taken by Jamie Milligan.74:06
Matt Phillips takes a shot from outside the box that bounces off the post.
The ball is delivered by Jamie Vardy, save made by Mark Howard.71:44
Peter Till takes a shot. Blocked by Robert Harris.71:27
Shaun Beeley crosses the ball, clearance made by Alex Baptiste.71:19
Junior Brown sends in a cross, Danny Wilson makes a clearance.70:55
Jamie Vardy has an effort at goal. Save made by Mark Howard.70:38
Corner taken by Jamie Milligan from the right by-line to the near post, clearance by Chris Basham.69:02 Goal scored
Goal! - Jamie Vardy - Fleetwood 1 - 3 Blackpool Jamie Vardy finds the back of the net with a goal from inside the box to the bottom right corner of the goal. Fleetwood Town 1-3 Blackpool.65:30
Peter Till produces a cross, Nathan Pond produces a header from deep inside the six-yard box that clears the crossbar.65:13
Corner from left by-line taken by Jamie Milligan.65:07
Centre by Peter Till, Chris Basham manages to make a clearance.64:57
Jamie Vardy takes a shot. Martinez Angel gets a block in.63:37
Handball by Neal Eardley. Free kick crossed right-footed by Andy Mangan from left wing.62:50
Shot from deep inside the area by Andy Mangan goes over the bar.62:11
Free kick awarded for an unfair challenge on Shaun Beeley by Ludovic Sylvestre. The free kick is delivered left-footed by Jamie Milligan from right wing, save made by Mark Howard.61:20
The official flags Peter Till offside. Indirect free kick taken by Danny Wilson.59:15
Thomas Ince challenges Shaun Beeley unfairly and gives away a free kick. Free kick taken by Scott Davies.58:23
Matt Phillips has a shot on goal from outside the box which misses right.57:40
Lomana Tresor LuaLua challenges Nathan Pond unfairly and gives away a free kick. Scott Davies takes the direct free kick.54:42
Assist on the goal came from Neal Eardley.54:42 Goal scored
Goal! - Thomas Ince - Fleetwood 0 - 3 Blackpool A goal is scored by Thomas Ince from inside the box to the top right corner of the goal. Fleetwood Town 0-3 Blackpool.54:41
Neal Eardley produces a cross,53:36
Foul by Matt Phillips on Nathan Pond, free kick awarded. Scott Davies takes the direct free kick.53:07
Junior Brown challenges Matt Phillips unfairly and gives away a free kick. Matt Phillips restarts play with the free kick.52:09
Free kick awarded for a foul by Alex Baptiste on Jamie Vardy. Free kick crossed by Jamie Milligan, Robert Harris manages to make a clearance.51:34
Outswinging corner taken left-footed by Jamie Milligan played to the near post, clearance made by Alex Baptiste.48:17
The ball is sent over by Peter Till, Headed effort from deep inside the penalty area by Jamie Vardy goes harmlessly over the crossbar.46:45
Assist by Robert Harris.46:45 Goal scored
Goal! - Matt Phillips - Fleetwood 0 - 2 Blackpool Matt Phillips gets on the score sheet with a goal from outside the penalty box to the top right corner of the goal. Fleetwood Town 0-2 Blackpool.45:01
The referee gets the second half underway.45:00 +2:16 Half time
Half Time The referee calls an end to the first half.45:00 +1:09
Free kick awarded for a foul by Andy Mangan on Thomas Ince. Ludovic Sylvestre produces a cross, Alex Baptiste has an effort at goal from deep inside the area missing to the right of the goal.45:00 +0:53
Thomas Ince takes a inswinging corner to the near post.45:00 +0:37
Matt Phillips takes a shot. Blocked by Steve McNulty.45:00 +0:26
Thomas Ince takes a shot. Save by Scott Davies.43:31
Shaun Beeley takes a shot. Blocked by Robert Harris.41:22
Jamie Milligan takes the direct free kick.41:22 Booking
Booking Danny Wilson receives a caution.40:57
Free kick awarded for a foul by Danny Wilson on Jamie Vardy.40:45
Lomana Tresor LuaLua sends in a cross, Scott Davies makes a save.40:19
Thomas Ince decides to take a short corner.40:13
Thomas Ince sends in a cross, Steve McNulty makes a clearance.39:25
Junior Brown crosses the ball, Effort from outside the penalty box by Jamie McGuire goes wide left of the goal.38:09
The ball is swung over by Jamie Vardy, Alex Baptiste makes a clearance.36:49
Free kick awarded for an unfair challenge on Jamie McGuire by Martinez Angel. Jamie Milligan takes the direct free kick.36:24
Shot by Jamie Vardy. Save by Mark Howard.35:47
Martinez Angel challenges Jamie McGuire unfairly and gives away a free kick. Jamie Milligan takes the free kick.34:52
The ball is sent over by Matt Phillips, Junior Brown makes a clearance.34:00
Robert Harris delivers the ball, save by Scott Davies.33:35
Jamie Vardy takes a shot. Comfortable save by Mark Howard.33:13
Outswinging corner taken by Jamie Milligan from the left by-line, Chris Basham manages to make a clearance.32:40
Andy Mangan takes a shot. Mark Howard makes a save.31:41
The ball is sent over by Neal Eardley, Scott Davies makes a save.30:50
Free kick awarded for an unfair challenge on Lomana Tresor LuaLua by Steve McNulty. Ludovic Sylvestre takes the direct free kick.29:29
Jamie Milligan delivers the ball, Alex Baptiste manages to make a clearance.28:26
The ball is sent over by Peter Till.27:53
Ludovic Sylvestre gives away a free kick for an unfair challenge on Andy Mangan. Free kick taken by Jamie Milligan.26:28
Jamie Milligan takes the inswinging corner, Matt Phillips makes a clearance.26:17
Peter Till takes a shot. Save made by Mark Howard.26:09
Jamie Vardy takes a shot. Save by Mark Howard.25:35
The ball is swung over by Peter Till.25:02
Jamie McGuire produces a cross, Ludovic Sylvestre gets a block in.23:44
Assist on the goal came from Martinez Angel.23:44 Goal scored
Goal! - Lomana Tresor LuaLua - Fleetwood 0 - 1 Blackpool Lomana Tresor LuaLua gets on the score sheet with a goal from inside the box low into the middle of the goal. Fleetwood Town 0-1 Blackpool.22:38
Effort on goal by Peter Till from just inside the area clears the bar.21:50
Unfair challenge on Peter Cavanagh by Chris Basham results in a free kick. Direct free kick taken by Jamie Milligan.20:58
Centre by Peter Till, Headed effort from inside the penalty area by Jamie Vardy misses to the right of the target.18:53
The offside flag is raised against Lomana Tresor LuaLua. Indirect free kick taken by Steve McNulty.17:34
Matt Phillips takes a shot. Save by Scott Davies.14:36
Neal Eardley crosses the ball.11:21
Free kick awarded for a foul by Junior Brown on Thomas Ince. Direct free kick taken by Neal Eardley.10:09
Corner taken by Thomas Ince.10:03
The ball is crossed by Chris Basham, Peter Cavanagh gets a block in.8:56
Lomana Tresor LuaLua is ruled offside. Free kick taken by Scott Davies.8:42
Short corner taken by Ludovic Sylvestre from the left by-line.8:32
Lomana Tresor LuaLua takes a shot. Nathan Pond gets a block in.7:51
Free kick awarded for a foul by Shaun Beeley on Matt Phillips. Free kick taken by Ludovic Sylvestre.7:05
The referee blows for offside. Mark Howard takes the indirect free kick.5:55
The ball is swung over by Robert Harris, save made by Scott Davies.3:43
The ball is swung over by Neal Eardley, Steve McNulty manages to make a clearance.3:01
Peter Cavanagh concedes a free kick for a foul on Chris Basham. Direct free kick taken by Alex Baptiste.1:29
Matt Phillips crosses the ball, Steve McNulty makes a clearance.0:18
Matt Phillips concedes a free kick for a foul on Shaun Beeley. Jamie Milligan restarts play with the free kick.0:00
The ref blows the whistle to begin the match.
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