Francois Zoko netted his sixth goal in as many games as Carlisle United eased past Leyton Orient.
The striker's low shot put the hosts ahead inside a minute and Matty Robson added the second from a free-kick.
Tom Taiwo's dipping shot from the edge of the area made it 3-0 at half-time and James Berrett skipped past two defenders to slot home the fourth.
Substitute Jamie Cureton nodded in Dean Cox's free-kick late on but it was a mere consolation for the O's.
VIEWS FROM THE DRESSING ROOM
Carlisle United assistant boss Graham Kavanagh told BBC Radio Cumbria:
"I think today was a really professional performance, very strong, very solid and I think the early goal really settled us down.
"To come away with a 4-1 victory, against a side who have been on a good run of form, is a great day's work.
"It gives us a good goal difference, we were in minus so we now jump into plus and we also cement ourselves in the top six."
Leyton Orient manager Russell Slade told BBC London 94.9:
"I'm disgusted with the first half and I thought it was really poor. The manner in which we conceded the goals has really upset me, I feel sick.
"A team that kept a clean sheet against Charlton and a clean sheet against Stevenage but defends like that in the first minute, I don't know where that came from.
"We were much better in the second half but the game was gone - it was already over by then. It is difficult to come back from 3-0 and we huffed and puffed but the damage was already done in the first period."
Live Text Commentary
Full Time The game is over, as the referee blows his whistle.90:00 +2:02
Free kick taken by Dean Cox.90:00 +2:02 Booking
Booking Peter Murphy goes into the book.90:00 +1:54
Peter Murphy gives away a free kick for an unfair challenge on Jamie Cureton.90:00 +0:29
Peter Murphy gives away a free kick for an unfair challenge on Jamie Cureton. Dean Cox delivers the ball from the free kick right-footed from right channel.89:05
Lee Cook is ruled offside. Adam Collin takes the indirect free kick.88:51
Short corner taken by Dean Cox.88:23
Lubomir Michalik gives away a free kick for an unfair challenge on Terrell Forbes. Matthew Spring takes the free kick.87:23
Paul Thirlwell takes a shot. Lee Butcher makes a save.84:15
Assist by Dean Cox.84:15 Goal scored
Goal! - Jamie Cureton - Carlisle 4 - 1 Leyton O Jamie Cureton finds the back of the net with a headed goal from inside the area. Carlisle 4-1 Leyton Orient.83:48
Free kick awarded for an unfair challenge on Kevin Lisbie by Francois Zoko. Dean Cox takes the free kick.82:46
Inswinging corner taken left-footed by Lee Cook from the left by-line, clearance by Lee Miller.81:59
Indirect free kick taken by Leon McSweeney.81:59 Substitution
Substitution Patrick Madden on for James Berrett.81:59
Matthew Robson challenges Matthew Spring unfairly and gives away a free kick.80:31
Kevin Lisbie takes a shot. Save by Adam Collin.78:12
Effort from deep inside the area by Jamie Cureton misses to the left of the goal.76:40 Substitution
Substitution Tom Taiwo goes off and Chris Chantler comes on.76:24 Substitution
Substitution Jamie Cureton replaces David Mooney.
Shot from just outside the area by David Mooney goes over the bar.75:48
Lubomir Michalik challenges Scott Cuthbert unfairly and gives away a free kick. Dean Cox restarts play with the free kick.74:13
Outswinging corner taken right-footed by James Berrett from the right by-line, Peter Murphy takes a shot. Adam Chicksen gets a block in.72:43 Goal scored
Goal! - James Berrett - Carlisle 4 - 0 Leyton O Goal scored by James Berrett from deep inside the penalty box to the bottom right corner of the goal. Carlisle 4-0 Leyton Orient.68:05
Lee Cook crosses the ball, Peter Murphy makes a clearance.66:34
Corner taken right-footed by James Berrett, Jimmy Smith makes a clearance.65:36
Francois Zoko produces a right-footed shot from inside the area that clears the crossbar.64:59
Leon McSweeney gives away a free kick for an unfair challenge on Matthew Robson. Adam Collin takes the free kick.61:49
Dean Cox decides to take a short corner.61:07 Substitution
Substitution Dean Cox replaces Marc Laird.57:47
Shot from just outside the box by James Berrett misses to the right of the goal.56:52
Paul Thirlwell takes a shot from just outside the penalty area which clears the crossbar.54:26
Kevin Lisbie fouled by Lubomir Michalik, the ref awards a free kick. Free kick taken by Matthew Spring.52:54
The ball is swung over by Frank Simek, clearance made by Terrell Forbes.50:33
Kevin Lisbie is flagged offside by the assistant referee. Peter Murphy takes the free kick.49:53
Foul by Jimmy Smith on Matthew Robson, free kick awarded. Adam Collin takes the direct free kick.48:09
Foul by Lee Miller on Terrell Forbes, free kick awarded. Indirect free kick taken by Lee Butcher.45:01
The referee blows his whistle to start the second half.45:00 +4:13 Half time
Half Time The ref blows to end the first period.45:00 +3:17
Unfair challenge on Jimmy Smith by Tom Taiwo results in a free kick. Strike on goal comes in from Lee Cook from the free kick, Adam Collin makes a save.45:00 +2:37
The referee blows for offside. Free kick taken by Lee Butcher.45:00 +2:00
Free kick awarded for a foul by Marc Laird on James Berrett. James Berrett takes the free kick.45:00 +0:40
Corner from the left by-line taken by Lee Cook, Paul Thirlwell manages to make a clearance.44:49
Foul by Terrell Forbes on Francois Zoko, free kick awarded. James Berrett takes the free kick.44:01
Effort from inside the six-yard box by David Mooney goes wide left of the target.43:02
Marc Laird concedes a free kick for a foul on Francois Zoko. Indirect free kick taken by Matthew Robson.42:04
The ball is delivered by Jon-Paul McGovern, James Berrett produces a header from deep inside the six-yard box that clears the crossbar.40:42
Shot from deep inside the area by Marc Laird clears the bar.39:34
Peter Murphy gives away a free kick for an unfair challenge on David Mooney. Matthew Spring takes the free kick.38:24
Foul by Marc Laird on James Berrett, free kick awarded. Indirect free kick taken by Adam Collin.37:28
Shot from just outside the penalty area by Marc Laird misses to the left of the target.36:26 Goal scored
Goal! - Tom Taiwo - Carlisle 3 - 0 Leyton O Tom Taiwo fires in a goal from just outside the penalty box to the top left corner of the goal. Carlisle 3-0 Leyton Orient.35:39
Lubomir Michalik takes a shot. Blocked by Leon McSweeney.35:06
Inswinging corner taken right-footed by James Berrett, save by Lee Butcher.33:02
Corner taken by James Berrett from the left by-line, save by Lee Butcher.29:55
The referee blows for offside. Free kick taken by Adam Collin.29:55 Goal scored
Goal! - Matthew Robson - Carlisle 2 - 0 Leyton O Matthew Robson grabs a goal direct from the free kick from outside the penalty area to the bottom left corner of the goal. Carlisle 2-0 Leyton Orient.29:19 Booking
Booking Scott Cuthbert booked for dissent.28:52
Scott Cuthbert is penalised for a handball.27:37
Free kick awarded for an unfair challenge on Scott Cuthbert by Lee Miller. Free kick taken by Lee Butcher.25:07
The assistant referee signals for offside against Lee Miller. Lee Butcher restarts play with the free kick.24:33
Short corner taken by James Berrett from the left by-line.23:00
Lubomir Michalik takes a shot. Terrell Forbes gets a block in.22:40
Free kick awarded for a foul by Scott Cuthbert on Lee Miller. James Berrett takes the free kick.22:04
Matthew Spring produces a right-footed shot from long range which goes wide right of the goal.20:51
Unfair challenge on Lee Cook by Peter Murphy results in a free kick. Indirect free kick taken by Matthew Spring.19:32 Substitution
Substitution Jimmy Smith joins the action as a substitute, replacing Stephen Dawson.16:17
Assist by Lee Miller.15:57
Tom Taiwo has shot on goal from just outside the area which goes wide of the right-hand upright.13:54 Booking
Booking Jon-Paul McGovern booked for unsporting behaviour.13:09
Effort from just outside the box by Lee Cook goes over the bar.12:45
Francois Zoko takes a shot. Scott Cuthbert gets a block in.10:22
The assistant referee signals for offside against Leon McSweeney. Adam Collin restarts play with the free kick.9:33
Unfair challenge on Kevin Lisbie by Peter Murphy results in a free kick. Leon McSweeney takes the free kick.8:18
Kevin Lisbie gives away a free kick for an unfair challenge on Paul Thirlwell. James Berrett crosses the ball from the free kick right-footed from right wing, Lee Miller concedes a free kick for a foul on Terrell Forbes. Indirect free kick taken by Lee Butcher.7:22
Free kick awarded for an unfair challenge on James Berrett by Marc Laird. Adam Collin takes the free kick.5:55
Tom Taiwo takes a shot. Lee Butcher makes a save.4:23
The assistant referee signals for offside against Kevin Lisbie. Indirect free kick taken by Peter Murphy.0:53 Goal scored
Goal! - Francois Zoko - Carlisle 1 - 0 Leyton O A goal is scored by Francois Zoko from inside the area to the bottom right corner of the goal. Carlisle 1-0 Leyton Orient.0:00
The game kicks-off.
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