Ali Al-Habsi saved a Charlie Adam penalty and made a string of other fine saves to help Wigan hold Liverpool to a point at the DW Stadium.
Luis Suarez won the second-half penalty when his overhead kick was handled by Gary Caldwell.
Dirk Kuyt also went close but he fired over from just six yards out.
Wigan played their part in a pulsating encounter and Hugo Rodallega could have snatched all three points with a header in the closing stages.
Liverpool enjoyed the best chances throughout, but their wastefulness in front of goal cost them victory in an open game that was theirs for the taking.
Wigan's footballing principles are laudable and this draw, coupled with the point picked up against Chelsea in their last outing , can give them plenty of confidence in their latest relegation battle.
During the pre-match warm-up, Liverpool's players joined manager Kenny Dalglish in sporting t-shirts with an image of Luis Suarez printed on the front.
The Uruguay forward has been banned for eight games and fined £40,000 by the FA for racially abusing Manchester United defender Patrice Evra at Anfield on 15 October.
The striker started the game - the suspension does not start until the appeal process is over - and was cheered and jeered in equal measure by the rival sets of supporters.
Liverpool have missed four penalties this season
And while Liverpool dominated in the opening half hour, Suarez was not the chief threat as he struggled to get into his stride.
It mattered very little while his team-mates were in such free-flowing form, with Al-Habsi making good saves from Jordan Henderson, Martin Skrtel, Dirk Kuyt and Glen Johnson before the home side finally broke into life.
While Wigan's slick passing game was getting them into trouble at the back, they were exciting in the final third and Roberto Martinez's side almost scored two goal-of-the-season contenders.
First, Mohamed Diame cracked a shot into the side-netting from 40 yards out and then Victor Moses embarked on an amazing run from his own half which only ended when his swerving shot was beaten clear by Jose Reina.
Suarez was brighter in the second half and had a free-kick tipped over the bar by Al-Habsi.
And he won a penalty in the 50th minute when his overhead effort was blocked by the hand of Caldwell.
Adam stepped up, but his spot-kick was spectacularly saved by Al-Habsi.
That appeared to knock the stuffing out of the visitors, who struggled to regroup.
However, they should have gone into the lead when Kuyt hooked over from just six yards out.
Wigan did enjoy good chances of their own, most notably when Rodallega's header was deflected behind by Johnson before Moses stabbed wide from the resulting corner.
But the points were destined to be shared, meaning it is now three games unbeaten for the ever-improving Latics, while Liverpool may live to rue two dropped points in the race for European qualification.
Wigan manager Roberto Martinez:
"It's not about the result, it's once more about the performance.
"We spoke about carrying on from Saturday. After the first 20 minutes, when we invited pressure by giving the ball away, we opened the game up and had some really good chances.
"We played eye-to-eye and it would have been a disaster to lose that game.
"It's another step forward."
Liverpool manager Kenny Dalglish:
"We're not out there to miss them (penalties)," he said.
"We're getting them, but you'd much rather be putting them away.
"In the second half we had most of the possession. We'll keep getting in there and see what happens.
"You feel for the players not taking opportunities, because we work really hard for them."
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Live Text Commentary
Full Time The game is over, as the referee blows his whistle.90:00 +3:51
Jonjo Shelvey takes a shot. Comfortable save by Ali Al Habsi.90:00 +2:38
Unfair challenge on Andy Carroll by Antolin Alcaraz results in a free kick. Shot comes in from Craig Bellamy from the free kick.90:00 +1:55
Inswinging corner taken by Craig Bellamy from the left by-line played to the near post, clearance by Gary Caldwell.90:00 +0:56
Craig Bellamy produces a right-footed shot from outside the penalty box and misses wide left of the target.90:00 +0:08
Antolin Alcaraz restarts play with the free kick.90:00 +0:08 Booking
Booking Booking for Craig Bellamy for dissent.89:58
Mohamed Diame fouled by Craig Bellamy, the ref awards a free kick.89:12
Unfair challenge on Sanchez Jose Enrique by Ronnie Stam results in a free kick. Sanchez Jose Enrique restarts play with the free kick.87:47
Free kick awarded for an unfair challenge on Charlie Adam by Victor Moses. Free kick taken by Charlie Adam.87:07
Shot from just outside the area by Hugo Rodallega goes over the bar.86:24 Substitution
Substitution (Liverpool) makes a substitution, with Andy Carroll coming on for Luis Suarez.85:05
The ball is delivered by Victor Moses, Hugo Rodallega takes a shot. Blocked by Glen Johnson. Corner taken by Ben Watson from the left by-line, Victor Moses produces a right-footed shot from close range which goes wide of the right-hand post.82:12
Maynor Figueroa fouled by Jordan Henderson, the ref awards a free kick. Ali Al Habsi takes the free kick.81:12
Maynor Figueroa takes a shot. Save by Jose Reina.79:35
Free kick awarded for a foul by Martin Skrtel on Franco Di Santo. Free kick taken by Gary Caldwell.78:08
Ben Watson delivers the ball from the free kick right-footed from left wing, Charlie Adam makes a clearance.78:08 Booking
Booking Glen Johnson booked.77:51
Free kick awarded for an unfair challenge on Franco Di Santo by Glen Johnson.77:00
Victor Moses sends in a cross, Martin Skrtel makes a clearance.
Mohamed Diame challenges Sanchez Jose Enrique unfairly and gives away a free kick. Sanchez Jose Enrique takes the direct free kick.75:28
Hugo Rodallega takes a shot. Blocked by Jordan Henderson.74:12
Unfair challenge on Hugo Rodallega by Stewart Downing results in a free kick. Direct free kick taken by Ali Al Habsi.72:30 Substitution
Substitution Ben Watson joins the action as a substitute, replacing David Jones.72:30 Substitution
Substitution Hugo Rodallega is brought on as a substitute for Jordi Gomez.72:30
Shot from just outside the penalty area by Jordan Henderson misses to the left of the target.71:05
Daniel Agger takes the direct free kick.71:05 Substitution
Substitution Dirk Kuyt goes off and Jonjo Shelvey comes on.71:05 Substitution
Substitution Craig Bellamy on for Rodriguez Maxi.71:05
Unfair challenge on Daniel Agger by Franco Di Santo results in a free kick.67:36
Inswinging corner taken by Stewart Downing.65:33
Centre by Charlie Adam, Shot on goal by Dirk Kuyt from inside the box goes harmlessly over the target.65:33 Booking
Booking Gary Caldwell booked for unsporting behaviour.65:19
Free kick awarded for an unfair challenge on Luis Suarez by Gary Caldwell.63:06
The ball is delivered by Sanchez Jose Enrique, Martin Skrtel has a headed effort from close range and clears the crossbar.62:41
Corner taken by Stewart Downing, clearance made by Gary Caldwell.60:27 Substitution
Substitution (Wigan) makes a substitution, with Franco Di Santo coming on for Conor Sammon.60:27
Sanchez Jose Enrique concedes a free kick for a foul on Ronnie Stam. Jordi Gomez restarts play with the free kick.59:16
Dirk Kuyt takes a shot. Save by Ali Al Habsi.58:55
Jordi Gomez takes a shot. Charlie Adam gets a block in.56:02
Jordi Gomez takes a shot. Jose Reina makes a save.50:34
Inswinging corner taken by Charlie Adam from the right by-line, Ali Al Habsi makes a save.50:22 Penalty
Penalty taken by Charlie Adam is saved by Ali Al Habsi. Wigan 0-0 Liverpool.49:32
Luis Suarez has an effort at goal from 20 yards. Blocked by Gary Caldwell. Handball by Gary Caldwell.47:58
Victor Moses takes a shot. Save by Jose Reina.45:59
Free kick awarded for an unfair challenge on Charlie Adam by Antolin Alcaraz. Strike on goal comes in from Luis Suarez from the free kick, Ali Al Habsi makes a save. Charlie Adam takes the outswinging corner, Martin Skrtel produces a header from inside the area that goes over the bar.45:01
The second half has started.45:00 +3:07 Half time
Half Time The ref blows to end the first period.45:00 +2:16
Ronnie Stam produces a cross, save made by Jose Reina.45:00 +1:22
Free kick awarded for a foul by Conor Sammon on Sanchez Jose Enrique. Sanchez Jose Enrique restarts play with the free kick.42:08
Antolin Alcaraz gives away a free kick for an unfair challenge on Luis Suarez. The free kick is swung in left-footed by Charlie Adam.40:19
David Jones takes a outswinging corner to the near post, clearance made by Glen Johnson.38:55
Outswinging corner taken left-footed by David Jones, Martin Skrtel manages to make a clearance. David Jones takes the inswinging corner, Daniel Agger makes a clearance.38:04
Luis Suarez gives away a free kick for an unfair challenge on Antolin Alcaraz. Direct free kick taken by Gary Caldwell.37:12
Unfair challenge on Jordi Gomez by Luis Suarez results in a free kick. Free kick taken by Ali Al Habsi.36:03
Victor Moses takes a shot. Jose Reina makes a save.33:43
Corner from the right by-line taken by Jordan Henderson, Mohamed Diame makes a clearance.31:31
Free kick awarded for a foul by David Jones on Glen Johnson. Free kick taken by Jose Reina.29:12
Victor Moses gives away a free kick for an unfair challenge on Glen Johnson. Martin Skrtel takes the free kick.28:25
David Jones takes a shot. Martin Skrtel gets a block in.27:50
Charlie Adam takes a shot. Save by Ali Al Habsi.26:57
Mohamed Diame takes a shot. Save by Jose Reina. Corner taken left-footed by David Jones, clearance made by Daniel Agger.26:06
Inswinging corner taken left-footed by Charlie Adam from the right by-line, clearance made by Gary Caldwell.25:44
Glen Johnson takes a shot. Save by Ali Al Habsi.24:31
Dirk Kuyt takes a shot. Ali Al Habsi makes a save. Corner taken left-footed by Charlie Adam from the right by-line, save by Ali Al Habsi. Shot on goal by Daniel Agger from just inside the area clears the crossbar.23:04
Jordi Gomez produces a left-footed shot from just outside the penalty area that goes harmlessly over the target.22:19
Long range shot from Mohamed Diame misses to the left of the target.22:02
Mohamed Diame fouled by Glen Johnson, the ref awards a free kick. Free kick taken by David Jones.21:00
Free kick awarded for a foul by Daniel Agger on Victor Moses. Gary Caldwell restarts play with the free kick.20:33
Maynor Figueroa takes a shot. Save made by Jose Reina.19:20
Shot from outside the area by Victor Moses misses to the left of the goal.18:38
Rodriguez Maxi takes a shot from just outside the penalty area clears the crossbar.16:40
Glen Johnson fouled by David Jones, the ref awards a free kick. Charlie Adam crosses the ball in from the free kick, clearance made by David Jones. Short corner taken by Rodriguez Maxi.15:08
David Jones takes a short corner.13:07
Corner taken by Charlie Adam from the right by-line, save made by Ali Al Habsi.12:45
Foul by James McCarthy on Glen Johnson, free kick awarded. Charlie Adam takes the free kick.11:53
Antolin Alcaraz challenges Luis Suarez unfairly and gives away a free kick. Jordan Henderson delivers the ball from the free kick right-footed from left channel, James McCarthy manages to make a clearance.11:14
Jordi Gomez gives away a free kick for an unfair challenge on Glen Johnson. Direct free kick taken by Jose Reina.10:59
The ball is delivered by Jordi Gomez, Martin Skrtel manages to make a clearance.10:09
Outswinging corner taken left-footed by David Jones from the left by-line, clearance by Martin Skrtel.9:27
The assistant referee flags for offside against Luis Suarez. Free kick taken by Ali Al Habsi.8:35
Charlie Adam takes a outswinging corner from the left by-line played to the near post. Martin Skrtel takes a shot. Save by Ali Al Habsi.8:04
Jordan Henderson takes a shot. Ali Al Habsi makes a save. Short corner taken by Stewart Downing.6:32
Unfair challenge on Rodriguez Maxi by Maynor Figueroa results in a free kick. Shot on goal comes in from Charlie Adam from the free kick.4:08
Corner taken by Stewart Downing from the left by-line played to the near post, James McCarthy manages to make a clearance.2:43
Free kick awarded for an unfair challenge on Maynor Figueroa by Luis Suarez. Direct free kick taken by Ali Al Habsi.2:26
A cross is delivered by Jordan Henderson, clearance by Gary Caldwell.0:30
Dirk Kuyt challenges Maynor Figueroa unfairly and gives away a free kick. Free kick taken by Maynor Figueroa.0:00
The referee gets the match started.
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