Burton saw off 10-man Macclesfield, who had substitute Vinny Mukendi sent off just 11 seconds after coming on.
Billy Kee scored the only goal when Elliott Hewitt gave the ball away to Jacques Maghoma and keeper Jose Veiga's initial save landed to the striker.
Ross Draper and Scott Boden both missed excellent chances for the visitors when well placed to score.
Half-time sub Mukendi saw red for elbowing Ryan Austin before Albion's Jimmy Phillips blew a great chance.
VIEWS FROM THE DRESSING ROOM
Burton boss Paul Peschisolido told BBC Radio Derby:
"I was disappointed with the fact they actually dominated in spells.
"However, good teams don't always play well but they get the results and today we showed that.
"We had a lot of long balls to deal with, a lot of long throw-ins to deal with and a lot of corner kicks to deal with, but defensively we were on it and so I was pleased with that."
Macclesfield Town manager Gary Simpson told BBC Radio Manchester:
"Coming off their players are saying it's (Vinny Mukendi's red card) never a sending off. I'd be a bit embarrassed if I had officiated this game today.
"A tremendous performance, the result just wasn't there but they worked their absolute socks off.
"We're picking up injuries left, right and centre so we might just have to have a look see if we can bring someone in."
Live Text Commentary
Full Time The referee signals the end of the game.90:00 +0:06
Greg Pearson takes a shot. Save made by Ross Atkins. Sam Wedgbury takes a inswinging corner from the left by-line to the near post, John McGrath manages to make a clearance. Nathaniel Brown takes a shot. Matthew Hamshaw fouled by Jimmy Phillips, the ref awards a free kick. Direct free kick taken by Jose Veiga. Free kick awarded for a foul by Jimmy Phillips on Matthew Hamshaw. Direct free kick taken by Matthew Hamshaw.86:13
Matthew Hamshaw takes a shot. Save by John McGrath. Short corner taken by Sam Wedgbury, Aaron Webster makes a clearance.85:41
Outswinging corner taken from the right by-line by Sam Wedgbury, Aaron Webster manages to make a clearance.83:01 Booking
Booking Adam Bolder receives a caution.82:51
Unfair challenge on George Donnelly by Adam Bolder results in a free kick. Direct free kick taken by Sam Wedgbury.81:53
Elliott Hewitt is ruled offside. Direct free kick taken by Aaron Webster.80:17 Substitution
Substitution Matthew Hamshaw joins the action as a substitute, replacing Lewis Chalmers.79:40
Greg Pearson takes a shot. Jose Veiga makes a save.79:18
Shot from just outside the box by Billy Kee misses to the left of the target.78:43
Waide Fairhurst takes a shot. Save made by Ross Atkins.77:00 Substitution
Substitution Greg Pearson is brought on as a substitute for Calvin Zola.77:00
Effort from deep inside the area by Jimmy Phillips misses to the right of the target.75:08
Carl Tremarco takes the direct free kick.75:08 Substitution
Substitution (Macclesfield) makes a substitution, with Waide Fairhurst coming on for Scott Boden.75:08
Free kick awarded for an unfair challenge on Carl Tremarco by Jimmy Phillips.74:36
The ball is delivered by Aaron Webster, Sam Wedgbury makes a clearance.73:40
Unfair challenge on Nathan Stanton by George Donnelly results in a free kick. Ross Atkins takes the free kick.72:11
Foul by Shaun Brisley on Calvin Zola, free kick awarded. Direct effort from the free kick comes in from Jacques Maghoma.71:12
Sam Wedgbury crosses the ball, clearance made by Ross Atkins.
Billy Kee produces a right-footed shot from just outside the penalty area that goes harmlessly over the target.68:40
Foul by Jimmy Phillips on Sam Wedgbury, free kick awarded. Lewis Chalmers takes the direct free kick.68:13
Elliott Hewitt delivers the ball, clearance made by John McGrath.66:58
Sam Wedgbury produces a left-footed shot from deep inside the penalty box which goes wide of the left-hand post.66:34
Sam Wedgbury delivers the ball, Ryan Austin manages to make a clearance.65:10
The ball is crossed by Jacques Maghoma, Calvin Zola takes a shot. Save by Jose Veiga.64:17 Booking
Booking The referee books Ryan Austin for unsporting behaviour.64:06
Ryan Austin concedes a free kick for a foul on Scott Boden. Lewis Chalmers takes the direct free kick.62:51 Substitution
Substitution Jimmy Phillips replaces Cleveland Taylor.61:51
Calvin Zola is flagged offside by the assistant referee. Jose Veiga takes the free kick.60:12
The ball is sent over by Billy Kee, Jose Veiga makes a clearance.58:27
Adam Bolder gives away a free kick for an unfair challenge on Lewis Chalmers. Lewis Chalmers takes the free kick.56:07
Outswinging corner taken by John McGrath from the left by-line played to the near post, Header from deep inside the penalty area by Billy Kee goes harmlessly over the crossbar.54:50
Scott Boden takes a shot from close range clearing the crossbar.53:05
Sam Wedgbury shoots direct from the free kick, save by Ross Atkins.53:05 Booking
Booking Andrew Corbett is shown a yellow card.51:23
Ross Draper concedes a free kick for a foul on Adam Bolder. Direct effort from the free kick comes in from Jacques Maghoma, save by Jose Veiga. Free kick awarded for an unfair challenge on Ross Draper by Andrew Corbett.50:37
Andrew Corbett delivers the ball.49:36
Short corner taken by Cleveland Taylor from the left by-line.47:52
Shot from outside the box by John McGrath misses to the left of the target.46:54
Free kick awarded for a foul by Vinny Mukendi on Ryan Austin. Direct free kick taken by Ross Atkins.46:13 Dismissal
Dismissal Vinny Mukendi shown a red card.45:30 Substitution
Substitution Vinny Mukendi replaces Tony Diagne.45:01
The second half has started.45:00 +4:06 Half time
Half Time The match has reached half-time.43:55
Corner taken by Sam Wedgbury, Nathaniel Brown takes a shot. Save by Ross Atkins.43:05
The referee gives a free kick against Scott Boden for handball. Ryan Austin takes the direct free kick.42:26
Free kick awarded for a foul by Adam Bolder on Sam Wedgbury. Jose Veiga restarts play with the free kick.41:06
Foul by Jacques Maghoma on Ross Draper, free kick awarded. Free kick crossed left-footed by Ross Draper, clearance by Ryan Austin.40:03
Free kick awarded for a foul by George Donnelly on Andrew Corbett. Free kick taken by Ryan Austin.39:22
Outswinging corner taken by Sam Wedgbury from the right by-line played to the near post, clearance made by Calvin Zola.38:56
The ball is sent over by Lewis Chalmers, clearance made by Aaron Webster.38:04
The referee blows for offside. Nathaniel Brown takes the direct free kick.34:28
A cross is delivered by Adam Bolder, Headed effort from deep inside the penalty area by Calvin Zola misses to the left of the goal.34:10
Centre by Billy Kee, Tony Diagne manages to make a clearance.33:35
Carl Tremarco concedes a free kick for a foul on Billy Kee. Free kick taken by John McGrath.31:28
Ross Draper produces a cross, John McGrath makes a clearance. Outswinging corner taken by Sam Wedgbury from the right by-line, The ball is sent over by Scott Boden, clearance by Adam Bolder. Inswinging corner taken by Sam Wedgbury.30:42
George Donnelly produces a cross, Ross Atkins makes a save.29:03
Tony Diagne gives away a free kick for an unfair challenge on Cleveland Taylor. Ryan Austin takes the direct free kick.27:28
The ball is delivered by Sam Wedgbury.26:53
Adam Bolder concedes a free kick for a foul on Lewis Chalmers. Free kick taken by Lewis Chalmers.25:08
The assistant referee flags for offside against Billy Kee. Direct free kick taken by Shaun Brisley.22:52
Scott Boden produces a drilled right-footed shot from deep inside the penalty box which goes wide of the left-hand post.22:05
Free kick taken by Jose Veiga.22:05 Booking
Booking Billy Kee goes into the referee's book.21:51
Lewis Chalmers fouled by Billy Kee, the ref awards a free kick.20:45
Corner taken by John McGrath from the right by-line, Headed effort from inside the box by Ryan Austin misses to the right of the target.15:06
Free kick awarded for a foul by Nathan Stanton on George Donnelly. Sam Wedgbury takes the free kick, The ball is sent over by Ryan Austin, Shaun Brisley makes a clearance. The ball is crossed by Adam Bolder, Corner from the right by-line taken by John McGrath, Ryan Austin takes a shot. Save made by Jose Veiga.12:36
Sam Wedgbury sends in a cross, clearance made by Ross Atkins.10:43
Assist on the goal came from Jacques Maghoma.10:43 Goal scored
Goal! - Billy Kee - Burton 1 - 0 Macclesfld Goal scored by Billy Kee from inside the penalty area high into the middle of the goal. Burton Albion 1-0 Macclesfield.9:47
Tony Diagne takes a shot. Save by Ross Atkins.8:54
Jacques Maghoma takes a shot. Save by Jose Veiga.5:43
Sam Wedgbury crosses the ball, Nathan Stanton makes a clearance. Outswinging corner taken right-footed by Sam Wedgbury from the right by-line, clearance by Aaron Webster.3:30
Elliott Hewitt produces a cross, outswinging corner taken from the right by-line by Sam Wedgbury, Scott Boden takes a shot. Ross Atkins makes a save.2:53
Tony Diagne fouled by Adam Bolder, the ref awards a free kick. Free kick taken by Lewis Chalmers.2:23
Ross Draper challenges John McGrath unfairly and gives away a free kick. Ryan Austin takes the free kick.0:19
The ball is sent over by Aaron Webster, Unfair challenge on Lewis Chalmers by Adam Bolder results in a free kick. Direct free kick taken by Jose Veiga. Clearance made by Carl Tremarco.0:00
The ref blows the whistle to start the match.
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