After Tuesday's game Pulis told BBC Radio 5 live just how vital Etherington is to his side.
"Everyone has their fingers crossed," he said. "We will do our best to try to get him on the pitch because he is important to us.
"It's a game that we'll desperately want him to play, and it's a game that Matt will desperately want to play. We will go to every measure we possibly can as a football club to give him the best opportunity."
Forward Ricardo Fuller will also miss the final after undergoing surgery on Tuesday for an Achilles injury suffered in Saturday's 1-1 draw at Aston Villa that will rule him out for four to six months.
"It's a bad blow for us," added Pulis. "If you look at the squad and the size of the club, we need our top players to be fit for us to be at our best.
"We are not Manchester City, we have not got multi-millionaires standing around waiting for their chances.
"This is a bread and butter football club, the players work very hard and we need everyone fit."
Stoke midfielder Rory Delap added: "It didn't look good after the game. We are all devastated if it is what everyone thinks it is.
"You never know with the scan but we are all thinking of him and we know how devastated he is.
"He's been a big part of this club and it will be devastating if Ricardo misses the final."
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