Scotland suffered a third defeat in the Clydesdale Bank 40 as Durham triumphed.
The visitors were put in to bat and posted 258 for four, thanks mainly to South African left-hander Jean Symes' top score of 110.
Mark Stonemen made his maiden one-day hundred and remained unbeaten on 136 off 117 balls and Phil Mustard posted 91 in an opening stand of 207.
And Scotland's Preston Mommsen conceded 20 runs in one over as Durham reached the winning total of 259 for two.
Graham Onions bowled well as Josh Davey fell for 13 but Symes and Calum MacLeod put on 86 in 15 overs before the latter edged the second ball of Mitch Claydon's second spell and wicketkeeper Mustard leapt to his right to make a brilliant one-handed catch.
Symes survived two very difficult chances to Mitch Claydon at deep backward square leg as he reached his 91-ball century, eventually bowled by the final ball.
Richie Berrington and Mommsen made useful contributions of 29 and 31 respectively but the former was caught by Paul Collingwood at deep mid-wicket by Gordon Muchall.
Stonemen and Mustard's partnership made a significant dent in Durham's total and, though Ben Stokes holed out at long-off for nine, Muchall went in with 14 needed and edged the hosts to victory.