8 May 2004, MGM Grand, Las Vegas - WBA and IBF super-featherweight title,
15 March 2008, Mandalay Bay, Las Vegas - WBC super-featherweight title,
PACQUIAO BY SPLIT DECISION
12 November 2011, MGM Grand, Las Vegas - WBO welterweight title,
PACQUIAO BY MAJORITY DECISION
8 December 2012, MGM Grand, Las Vegas - non-title,
MARQUEZ BY SIXTH-ROUND KO
That fight - the third of their series - gave Marquez his sixth defeat of a career spanning nearly two decades.
It is a career that has seen him win the WBA featherweight title, the WBC super-featherweight title and the WBO and WBA lightweight titles.
After the fight, Pacquiao, who was leading 47-46 on all three judges' scorecards, said he will seek a fifth meeting with Marquez, who now has 55 wins, six defeats and one draw.
"Why not? It's a good fight," said Pacquiao. "I did my best. I know that I got him in the last couple of rounds but I started to be over-confident and I got hit by a solid punch. I did not expect that punch."
Marquez said: "I am not thinking about any fight. I just want to celebrate.
"Right now in my future I don't know what is coming but I am going to rest and I am going to celebrate with my family and my friends in Mexico."
Asked whether Pacquiao should continue, his trainer Freddie Roach said he would assess his charge in the gym and make a decision.
"If I see him declining in the gym and I think he's going to get hurt I'll tell him to retire and I think he will if I tell him," Roach told BBC Sport.
"He was boxing well and winning the round big and he walked into a short, picture-perfect punch."
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