Not many people had real friends in the American West in the 1930s - it was a case of every man for himself. That is one of the reasons why the story of George and Lennie's unusual friendship is so poignant. They have each other. No one else in the novel is so lucky.
"...with us it ain't like that. We got a future. We got somebody to talk to that gives a damn about us. We don't have to sit in no bar room blowin' in our jack 'jus because we got no place else to go. If them other guys gets in jail they can rot for all anybody gives a damn. But not us."
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