Thierry Henry and Alan Shearer join Gary Lineker for highlights and analysis of the day's seven Premier League matches. Manchester City welcome Arsenal to the Etihad Stadium, a venue where the Gunners have tasted victory only once in their last five visits.
Southampton make the long journey to Newcastle looking to record their first win at St James' Park since 1997. Everton take on Fulham at Goodison Park - in all but four of their 24 previous Premier League meetings, the side at home has taken the points.
Meanwhile, Chelsea entertain Crystal Palace in a London derby at Stamford Bridge, Cardiff host West Brom, West Ham play Sunderland and Stoke travel to Hull.