Dotun Adebayo takes you through the night, with interviews about stories from around the world, updates from the BBC's foreign correspondents, and regular news and sport updates.
There's a look at the week's medical news with Up All Night's doctors, Mark Hamilton or Raj Thakkar.
And from 2.35am, your chance to take part in the Friday phone-in. Call 0500 909 693 [free from most landlines; other networks and mobiles may charge]. Text 85058 [standard rate]. Email email@example.com.