With Professor Brian Cox and Sinead O'Connor
Wednesday sees Professor Brian Cox on the show for his weekly science chat.
Brian is a TV presenter, professor, particle physicist and Royal Society University Research Fellow who is currently working at CERN. He's also in charge of single-handedly making science cool.
Shaun, on the other hand, is in charge of pure silliness and a soundtrack of superb tracks, both old and new, to help you kick out the jams!
Plus, singer Sinead O'Connor chats to Shaun about life, her latest album 'How about I Be Me (And you Be You)?' and the new single '4th and Vine'.
An Irish singer-songwriter, Sinead rose to fame in the late 1980s with her debut album 'The Lion and the Cobra'. O'Connor achieved worldwide success in 1990 with a cover of Prince's song "Nothing Compares 2 U". Since then, while maintaining her singing career, she has occasionally encountered controversy, partly due to her statements and gestures - such as her ordination as a priest despite being a woman with a Roman Catholic background - and her strongly expressed views on organised religion, and women's and children's rights.