Gary Lineker introduces highlights of the day's Premier League games, with expert analysis from Mark Lawrenson and Alan Shearer.
Sir Alex Ferguson's Manchester United host Alan Pardew's Newcastle, with the Tynesiders looking for their first win at Old Trafford since 1972.
Roberto Mancini takes his Manchester City side to the Stadium of Light, where they suffered a 1-0 defeat by Sunderland in January.
The Emirates plays host to a London derby between Arsenal and West Ham, Tottenham travel to Aston Villa and Norwich welcome Chelsea to Carrow Road. There are also games between Everton and Wigan, Fulham and Southampton, QPR and West Brom, Reading and Swansea, and Stoke and Liverpool.