Gary Lineker introduces highlights from the Premier League, with Mark Lawrenson and Alan Shearer offering their assessment of the action.
Manchester United host Newcastle, whose last victory at Old Trafford was in 1972. Sir Alex Ferguson's men are looking to extend their 10-year unbeaten run against the Magpies, whose last success in this fixture was a 4-3 win in September 2001 when Alan Shearer grabbed the winner.
Chelsea take on Wolves at Stamford Bridge, looking to avenge their defeat the last time the sides met, at Molineux in January.
Arsene Wenger's Arsenal welcome Fulham to the Emirates for a London derby, while Norwich and QPR, who both won automatic promotion to the Premier League last season, meet at Carrow Road.
Elsewhere there's a north-west derby between Bolton and Everton, Wigan travel to Sunderland, and West Brom host Tottenham.