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23/05/2013

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The Origins of Infectious Disease

Duration:
45 minutes
First broadcast:
Thursday 09 June 2011

Melvyn Bragg and his guests discuss the origins of infectious disease.

Infectious disease has been with us for millennia. There are reports of ancient outbreaks of plague in the Bible, and in numerous historical sources from China, the Middle East and Europe. Other infections, including smallpox, tuberculosis and measles, have also been known for centuries. But some diseases made their first appearances only recently: HIV emerged around a century ago, while the Ebola virus was first recorded in the 1970s.

But where do the agents of disease come from, and what determines where and when new viruses and bacteria appear? Modern techniques allow scientists to trace the histories of infective agents through their genomes; the story of disease provides a fascinating microcosm of the machinery of evolution.

With:

Steve Jones
Professor of Genetics at University College London

Sir Roy Anderson
Professor of Infectious Disease Epidemiology at Imperial College London

Mark Pallen
Professor of Microbial Genomics at the University of Birmingham.

Producer: Thomas Morris.

  • FURTHER READING

    William H. McNeil, ‘Plagues and Peoples’ (Anchor, 1977, new edition 1998)

    Jared Diamond, ‘Guns, Germs and Steel’ (Vintage, new edition 2005)

    Carl Zimmer, ‘A Planet of Viruses’ (University of Chicago Press, 2011)

    Richard Preston, ‘The Hot Zone’ (Anchor, 1995)

    Paul de Kruif, ‘Microbe Hunters’ (Mariner Books; 70th edition, 1996)

    Hans Zinsser, ‘Rats, Lice and History’ (Back Bay Books, 1994)

    Dorothy Crawford, ‘Deadly Companions: How Microbes Shaped Our History’ (OUP Oxford, 2007)

    Dorothy Crawford, ‘The Invisible Enemy: A Natural History of Viruses’ (OUP Oxford; New Ed edition 2002)

    R. M. Anderson & R. M. May, ‘Infectious Diseases of Humans’ (Oxford University Press, 1991)

    S. A. Frank, ‘Immunology and Evolution of Infectious Disease’ (Princeton University Press, Princeton US, 2000)

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