Boris Johnson, Diane Abbott and Clive Anderson join the topical debate from London.
In London, the panel includes Danny Alexander, Ken Livingstone and Bianca Jagger.
The guests include Baroness Warsi, Chris Bryant, Simon Hughes and Kelvin MacKenzie.
Broadcaster Nick Ferrari joins the topical debate programme from Edinburgh.
In Derby, the panel includes Iain Duncan Smith, Margaret Beckett and David Starkey.
BBC One Northern Ireland
BBC One except Northern Ireland