Kesha tops worldwide digital single sales in 2010
Kesha's debut track Tik Tok was the biggest-selling digital single in the world last year.
It sold 12.8 million copies, three million more than Lady Gaga's Poker Face which topped the chart in 2009.
The track, which made it to number four in the UK singles chart, beat Lady Gaga's Bad Romance and Eminem's Love The Way You Lie in the 2010 chart.
The sales figures were released by the International Federation of the Phonographic Industry (IFPI).
The industry body, which represents 1,400 record companies in 66 countries, said worldwide digital revenues had gone up by 6% to $4.6 billion (£2.8 billion) but piracy was still costing jobs.
IFPI chief executive Frances Moore said: "As we enter 2011, digital piracy, and the lack of adequate legal tools to fight it, remains the biggest threat to the future of creative industries.
"Great new legitimate music offerings exist all over the world, offering consumers a wide range of ways to access music.
"Yet they operate in a market that is rigged by piracy, and they will not survive if action is not taken to address this fundamental problem.
"This is the challenge and the opportunity for governments to seize in 2011."
Digital albums rose 29% in the UK, but the report says digital piracy is "growing rapidly" and illegal file-sharing remains "rife" with 76% of music obtained online in the UK unlicensed.
The top 10 digital single worldwide in 2010 were:
1. Tik Tok by Kesha - 12.8 million copies
2. Bad Romance by Lady Gaga - 9.7m
3. Love The Way You Lie by Eminem featuring Rihanna - 9.3m
4. Telephone by Lady Gaga - 7.4m
5. OMG by Usher featuring will.i.am - 6.9m
6. California Gurls by Katy Perry - 6.7m
7. Hey, Soul Sister by Train - 6.6m
8. Baby by Justin Bieber - 6.4m
9. I Gotta Feeling by Black Eyed Peas - 6.1m
10. crushcrushcrush by Paramore - 6.1m