Profile: Amanda Knox
US student Amanda Knox effectively faces a retrial for the brutal murder of her UK flatmate Meredith Kercher in Italy in 2007, in a case which gripped the media on both sides of the Atlantic.
She served four years in an Italian prison for the murder, always insisting on her innocence. In 2011, she was acquitted on the basis of flawed DNA evidence but prosecutors have now successfully appealed and her acquittal has been struck down. The appeal process will now be re-run.
Her former boyfriend, Italian student Raffaele Sollecito, also had his acquittal over the killing struck down, while the third key figure in the original investigation, Ivorian drifter Rudy Guede, is serving a 16-year prison sentence for the murder.
Reacting to the "painful" news that her acquittal had been cancelled, Miss Knox again insisted she was innocent, saying in a statement: "The prosecution's theory of my involvement in Meredith's murder has been repeatedly revealed to be completely unfounded and unfair."
It is likely the new appeals process will be held in absentia. Ms Knox, 25, is now back at university in her home state of Washington.
During her time in Italy, her private life was picked apart relentlessly both in court and in the media.'Mask of a murderer'
The facts of the case are that Miss Kercher's body was found in her bedroom in the house she shared with Miss Knox and others in Perugia, an Italian university town where the two young women were exchange students. Her throat had been slashed.
Prosecutors argue that Miss Kercher was the victim of a drug-fuelled sex game gone wrong.
Both Miss Knox and Mr Sollecito denied any guilt, saying they were not even in the apartment that night, although they admitted having smoked marijuana and that their memories may have been clouded.
In court in Italy, Miss Knox said she feared "having the mask of a murderer forced on to" her skin.
Her seemingly innocent insouciance contrasted gratingly with the gory crime and general preconceptions of what a murderer should look like, Dan Bell wrote for BBC News in 2010.
The explanation offered by prosecutors and feverish media was that she was that most-loved of villains - the middle-class monster whose appearance hides a diabolical soul, he said.
One Italian commentator described her as having "the face of an angel but the eyes of a killer".
A lawyer reportedly accused her of being "dirty inside and out", a "she-devil, a diabolical person focused on sex, drugs and alcohol, living life to the extreme and borderline".'Inappropriate' reaction
Elements of her reaction to the murder and her lifestyle in Italy appear to have driven this determination to demonise Miss Knox.
As she waited to be questioned in a police station, she reportedly "did the splits and a cartwheel in one of the rooms", according to a senior police official, quoted by the UK's Daily Telegraph newspaper.
"I told them it was not appropriate," the official, Domenico Giacinto Profazio, later said in court.
Reporters who dug up her past life in Seattle found the University of Washington student had been fined in 2007 for her role in a drunken party that police were called to.
A picture was painted of a "party girl" who abused drink and drugs and had an active sex life.
It emerged that she had written a short story on a social networking site about a man who drugs and rapes a young girl. In it, one character remarks: "A thing you have to know about chicks is that they don't know what they want."
In letters to his father from prison, Raffaele Sollecito wrote: "The Amanda I know... lives a carefree life... Her only thought is the pursuit of pleasure."
But he added: "Even the thought that she could be a killer is impossible for me."
After his release, Mr Sollecito said they were no longer in a relationship and Miss Knox had found a new boyfriend.'Heads held high'
She is living back in her home city Seattle and studying creative writing, said David Marriott, the Knox family media adviser, quoted by the New York Times.
A book she has written, Waiting to Be Heard, is due to be published on 30 April, when she will give her first interview since leaving prison, to US broadcaster ABC.
Her family have stood by her, reportedly spending huge sums of money on lawyers and publicists, as well as travel and living costs, during the fight to free their daughter.
They had helped fund their daughter's year in Italy in order to further her Italian, German and creative writing studies.
Another image of Miss Knox at the time of the murder is that of a non-drinker and non-smoker, who declared her favourite pursuits to be yoga and backpacking.
This was a young woman who listed among her favourite films Shrek and The Full Monty, and who liked listening to The Beatles and reading Harry Potter books.
On a tribute website, family and friends wrote about the "joiner" who excelled at sports and school plays; a "smart, fun, affectionate and loyal" girl who bought sandwiches for homeless people and nursed sick friends.
Reacting to news of the new appeals process, her lawyer, Carlo Dalla Vedova, said: "She thought the nightmare was over."
In her own statement, Miss Knox said: "No matter what happens, my family and I will face this continuing legal battle as we always have, confident in the truth and with our heads held high in the face of wrongful accusations and unreasonable adversity."