Is injury toll in rugby growing?
31 January 2013 Last updated at 08:42 GMT
The Welsh team to face Ireland will be announced later, but selecting the team for this year's campaign may well have been a bit more of a headache due the number of injuries.
But is having so many players confined to the sidelines a case of bad luck - or is it because the professional game is taking an ever greater toll on players' bodies?
BBC Wales health correspondent Owain Clarke reports.